Research Publications (from 2000):

Saken, E.*, Rakin, A.*, and Heesemann, J. (2000). Molecular characterization of a novel siderophore-independent iron transport system in Yersinia.  Inter.J.Med.Microbiol. 15, 1-10.

Rakin, A., Schubert, S., Guilvout, E. Carniel and J. Heesemann. (2000). Local hopping of IS3 elements into the A+T-rich part of the high-pathogenicity island in Yersinia enterocolitica 1B, O:8. FEMS Microbiol. Lett., 182, 225-229.

Rakin, A., C. Noelting, P. Schropp and J. Heesemann. (2001). Integrative module of the high-pathogenicity island of Yersinia. Mol. Microbiol., 39, 407-415.
Brem, D., C. Pelludat, A. Rakin, C.A. Jacobi and J. Heesemann. (2001). Functional analysis of yersiniabactin transport genes of Yersinia enterocolitica. Microbiology, 147, 1115-1127.

Jacobi, C., Gregor, S., Rakin, A. and J. Heesemann. (2001). Expression analysis of the yersiniabactin receptor gene fyuA and the heme receptor hemR of Yersinia enterocolitica in vitro and in vivo using the reporter genes for green fluorescent protein and luciferase. Infect. Immun., 69, 7772-7782.

Iwobi, A., Rakin, A., Garcia, E., Heesemann, J. 2002. Representational difference analysis uncovers a novel IS10-like insertion element unique to pathogenic strains of Yersinia enterocolitica. FEMS Microbiol. Lett., 210: 251-255.

Antonenko V., Pawlow V., Heesemann J., Rakin A. 2003. Characterisation of a novel unique restriction-modification system from Yersinia enterocolitica O:8 1B. FEMS Microbiol. Lett., 219:249-252.

Iwobi, A., Heesemann, J., Garcia, E., Igwe, E., Noelting, C., and Rakin, A. 2003. A novel virulence-associated type II secretion system unique to highly pathogenic group of Y. enterocolitica 1B. Infect. Immun., 71:1872–1879.

Iwobi A., Rakin A., Garcia E., Heesemann J . Subtractive hybridization uncovers novel pathogenicity-associated loci in Yersinia enterocolitica. Adv Exp Med Biol 2003, 529:25-9.
Rakin A., Golubov A., Iwobi A., Heesemann J . Tracing acquisitions and losses in Yersinia genomes. Adv Exp Med Biol 2003, 529:19-23.

Stewart J. Hinchliffe, Karen E. Isherwood, Richard A. Stabler, Michael B. Prentice, A. Rakin, Richard A. Nichols, Petra C.F. Oyston, Jason Hinds, Richard W. Titball, and Brendan W. Wren. Application of DNA Microarrays to Study the Evolutionary Genomics of Yersinia pestis and Yersinia pseudotuberculosis Genome Res. 2003;13 2018-2029.

Tomaso H., Reisinger E.C., Al Dahouk S., Frangoulidis D., Rakin A., Landt O., Neubauer H. Rapid detection of Yersinia pestis with multiplex real-time PCR assays using fluorescent hybridisation probes. FEMS Immunol Med Microbiol 2003, 38:117-26.

Golubov A, Heesemann J, Rakin A. Uncovering genomic differences in human pathogenic Yersinia enterocolitica. FEMS Immunol Med Microbiol 2003, 38:107-11.

Rakin, A. Yersinia pestis. Eine Bedrohung für die Menschheit. Bundesgesundheitsblatt Gesundheitsforsch.Gesundheitsschutz. 2003, 46: 949-955.

Gierczynski R, Kaluzewski S, Rakin A, Jagielski M, Zasada A, Jakubczak A, Borkowska-Opacka B, Rastawicki W.     Intriguing diversity of Bacillus anthracis in eastern Poland - the molecular echoes of the past outbreaks. FEMS Microbiol Lett. 2004, 15;239(2):235-40.

Golubov A, Neubauer H, Nolting C, Heesemann J, Rakin A. Structural organization of the pFra virulence-associated plasmid of rhamnose-positive Yersinia pestis. Infect Immun. 2004 Oct;72(10):5613-21.

Schubert S., Rakin, A., Heesemann J. The Yersinia high-pathogenicity island (HPI): evolutionary and functional aspects. Int J Med Microbiol., 2004 294:83-94.
Rakin A. Yersinia: molecular and cellular biology. Expert Rev Anti Infect Ther. 2005 Jun;3(3):321-3.    

Anisimov R, Brem D, Heesemann J, Rakin A. Transcriptional regulation of high pathogenicity island iron uptake genes by YbtA. Int J Med Microbiol. 2005 Apr;295(1):19-28.

Antonenka, U., Nölting, Ch., J. Heesemann and Rakin A. Horizontal transfer of Yersinia high-pathogenicity island by the conjugative RP4attB target presenting shuttle plasmid. Molecular Microbiology 2005, 57 (3), 727-734.
Golubov, A., Gierczynski R., Heesemann J. and Rakin A. A novel insertion sequence element, ISYen2, as an epidemiological marker for weakly pathogenic bioserotypes of Yersinia enterocolitica. Int J Med Microbiol. 2005 Aug;295(4):213-26.

Anisimov R, Brem D, Heesemann J, and Rakin A. Molecular mechanism of YbtA-mediated transcriptional regulation of divergent overlapping promoters ybtA and irp6 of Y. enterocolitica. FEMS Microbiol Lett. 2005 Sep 1;250(1):27-32.
Antonenka, U., Nölting, Ch., J. Heesemann and Rakin A. Independent acquisition of site-specific recombination factors by asn tRNA gene-targeting genomic islands. Int J Med Microbiol. 2006 Oct;296(6):341-52.

Tomaso, H., Al Dahouk, S., Reisinger, E. C., Rakin, A., Neubauer, H. Yersinia pestis – der schwarze Tod im neuen Kleid. In: Infektiologie. Aktuelle Aspekte. O. Janata E. Reisinger, eds. ÖVG, Wien, 2006, 165-178.

Vergnaud G., Li Y., Gorgé, O., Song Y., Cui Y., Zhou D., Grissa I., Dentovskaya S., Platonov M., Rakin A., Balakhonov S., Neubauer H., Pourcel C., Anisimov A., Yang R. Analysis of the Three Yersinia pestis CRISPR Loci in Combination with Polymorphic Tandem Repeats Typing Provides New Tools for Phylogenetic Studies and Possibly for the Investigation of Ancient DNA. In: The Genus Yersinia: From Genomics to Function. Eds. R. D. Perry and J. D. Fetherston. Springer, New York, 2007. P.327-338.

Gierczyński, R., Golubov, A., Neubauer, H., Pham J. N. and Rakin, A. Development of a multiple-locus variable-number tandem repeat analysis (MLVA) for Yersinia enterocolitica palearctica and its application to bioserogroup 4/O3 subtyping.  J Clin Microbiol. 2007 Aug;45(8):2508-15.

Wang X, Han Y, Li Y, Guo Z, Song Y, Tan Y, Du Z, Rakin A, Zhou D, Yang R. Yersinia genome diversity disclosed by Yersinia pestis genome-wide DNA microarray. Can J Microbiol. 2007, (11):1211-21.

Rakin, A., Noelting, C., Heesemann, J. Recombination activity of the minimal integrative module of the High-Pathogenicity Island of Yersinia pestis. In: Peste: entre épidemies et sociétés. Plague: epidemics and societes. Signoli, M., Chevé, D., A., et al eds. 2007, P. 271-275.

Reissbrodt, R., Hammes W. P., dal Bello F., Prager, R., Fruth, A., Hantke, K., Rakin, A.,  Starcic-Erjavec, M. Inhibition of shigatoxin production and growth of enterohaemorrhagic Escherichia  coli (EHEC) by a non-pathogenic Escherichia coli (Probus). FEMS Microbiol. Lett., 2007, in press.

Hartmann, H., Eltzschig, H. K., Wurz, H., Hantke, K., Rakin, A., Yazdi, A. S., Matteoli, G., Bohn, E., Autenrieth, I. B., Karhausen, J., Neumann, D. , Colgan, S. P.  and Kempf, V. A. Hypoxia-independent activation of hypoxia inducible factor-1 by Enterobacteriaceae. Gastroenterology, 2008 Mar ;134 (3):756-767.