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Research > Medical Microbiology and Hospital Epidemiology > WG Prof. R. Haas > 

Helicobacter pylori

Helicobacter pylori is a very successful bacterial pathogen, colonising the gastric mucosa of about 50 % of the world´s population. The persistent infection causes chronic gastritis and often gastric or duodenal ulceration and raises the risk to develop malignant gastric disorders, such as gastric cancer or MALT lymphoma. Our group is investigating the molecular mechanisms of the specific pathogen host interaction, and the question how the pathogen modulates different types of host cells to cause disease. In the focus of our research are the different H. pylori Type 4 Secretion Systems (T4SS) and the vacuolating cytotoxin (VacA) and its mechanism of binding, uptake and immunomodulation on leucocytes, especially T-lymphocytes and dendritic cells.

In addition, we study H. pylori DNA transfer mechanisms via natural transformation and conjugation under in vitro or in vivo conditions using the Mongolian gerbil animal model. (more …)