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Forschung > Medizinische Mikrobiologie und Krankenhaushygiene > AG Fischer > Publikationen > 


Messerer, M., Fischer, W., Schubert, S. (2017) Investigation of horizontal gene transfer of pathogenicity islands in Escherichia coli using next-generation sequencing. PLoS One (in press).

Harrison, U., Fowora, M.A., Seriki, A.T., Loell, E., Mueller, S., Ugo-Ijeh, M., Onyekwere, C.A., Lesi, O.A., Otegbayo, J.A., Akere, A., Ndububa, D.A., Adekanle, O., Anomneze, E., Abdulkareem, F.B., Adeleye, I.A., Crispin, A., Rieder, G., Fischer, W., Smith, S.I., Haas, R. (2017) Helicobacter pylori strains from a Nigerian cohort show divergent antibiotic resistance rates and a uniform pathogenicity profile. PLoS One 12: e0176454.

Santos, J.C., Brianti, M.T., Almeida, V.R., Ortega, M.M., Fischer, W., Haas, R., Matheu, A., Ribeiro, M.L. (2017) Helicobacter pylori infection modulates the expression of miRNAs associated with DNA mismatch repair pathway. Mol. Carcinog. 56: 1372-1379 (doi: 10.1002/mc.22590).

Bönig, T., Olbermann, P., Bats, S.H., Fischer, W., Josenhans, C. (2016) Systematic site-directed mutagenesis of the Helicobacter pylori CagL protein of the Cag type IV secretion system identifies novel functional domains. Sci. Rep. 6: 38101 (doi: 10.1038/srep38101).

Königer, V., Holsten, L., Harrison, U., Busch, B., Loell, E., Zhao, Q., Bonsor, D.A., Roth, A., Kengmo-Tchoupa, A., Smith, S.I., Mueller, S., Sundberg, E.J., Zimmermann, W., Fischer, W., Hauck, C.R., Haas, R. (2016) Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. Nat. Microbiol. 2: 16188 (doi: 10.1038/ NMICROBIOL.2016.188) (Erratum: Nat. Microbiol. 2: 16233).

Zhong, Y., Anderl, F., Kruse, T., Schindele, F., Jagusztyn-Krynicka, E.K., Fischer, W., Gerhard, M., Mejías-Luque, R. (2016) Helicobacter pylori HP0231 influences bacterial virulence and is essential for gastric colonization. PLoS One 11: e0154643.

Schindele, F., Weiss, E., Haas, R., Fischer, W. (2016) Quantitative analysis of CagA type IV secretion by Helicobacter pylori reveals substrate recognition and translocation requirements. Mol. Microbiol. 100: 188-203.

Vallese, F., Percudani, R., Fischer, W., Zanotti, G. (2015) The crystal structure of Helicobacter pylori HP1029 highlights the functional diversity of the sialic acid-related DUF386 family. FEBS J. 282: 3311-3322.

Backert, S., Tegtmeyer, N., Fischer, W. (2015) Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system. Future Microbiol. 10: 955-965.

Bonsor, D.A., Pham, K.T., Beadenkopf, R., Diederichs, K., Haas, R., Beckett, D., Fischer, W., Sundberg, E.J. (2015) Integrin engagement by the helical RGD motif of the Helicobacter pylori CagL protein is regulated by pH-induced displacement of a neighboring helix. J. Biol. Chem. 290: 12929-12940.

Busch, B., Weimer, R., Woischke, C., Fischer, W., Haas, R. (2015) Helicobacter pylori interferes with leukocyte migration via the outer membrane protein HopQ and via CagA translocation. Int. J. Med. Microbiol. 305: 355-364.

Fischer, W., Breithaupt, U., Kern, B., Smith, S.I., Spicher, C., Haas, R. (2014) A comprehensive analysis of Helicobacter pylori plasticity zones reveals that they are integrating conjugative elements with intermediate integration specificity. BMC Genomics 15: 310.

2013                                                                                                                                                                                                    Bonsor, D.A., Weiss, E., Iosub-Amir, A., Reingewertz, T.H., Chen, T.W., Haas, R., Friedler, A., Fischer, W., Sundberg, E.J. (2013) Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF. J. Biol. Chem. 288: 32897-32909.

Pham, K.T., Fischer, W. (2013) Helicobacter pylori utilizes DNA shuffling to modulate the gastric inflammatory response. Future Microbiol. 8: 835-838.

Fischer, W., Busch, B. (2013) The Helicobacter pylori CagA protein: A multifunctional bacterial toxin delivered by type IV secretion. In: Bacterial Toxins: Genetics, Cellular Biology and Practical Applications; T. Proft, Ed., Caister Academic Press, Norfolk, UK; pp. 13-45.

Rohrer, S., Holsten, L., Weiss, E., Benghezal, M., Fischer, W., Haas, R. (2012) Multiple pathways of plasmid DNA transfer in Helicobacter pylori. PLoS One 7: e45623.

Pham, K.T., Weiss, E., Jiménez Soto, L.F., Breithaupt, U., Haas, R., Fischer, W. (2012) CagI is an essential component of the Helicobacter pylori Cag type IV secretion sys-tem and forms a complex with CagL. PLoS One 7: e35341.

Fischer, W. (2011) Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus. FEBS J. 278, 1203-1212.

Jurik, A., Haußer, E., Kutter, S., Pattis, I., Praßl, S., Weiss, E., and Fischer, W. (2010) The coupling protein Cagß and its interaction partner CagZ are required for type IV secretion of the Helicobacter pylori CagA protein. Infect. Immun. 78, 5244-5251.

Fischer, W., Windhager, L., Rohrer, S., Zeiller, M., Karnholz, A., Hoffmann, R., Zimmer, R., and Haas, R. (2010) Strain-specific genes of Helicobacter pylori: Genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res. 38, 6089-6101.

Ding, S.-Z., Fischer, W., Kaparakis-Liaskos, M., Liechti, G., Merrell, D.S., Grant, P.A., Ferrero, R.L., Crowe, S.E., Haas, R., Hatakeyama, M., and Goldberg, J.B. (2010) Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. PLoS One 5, e9875.

Jiménez-Soto, L.F., Kutter, S., Sewald, X., Ertl, C., Weiss, E., Kapp, U., Rohde, M., Pirch, T., Jung, K., Retta, S.F., Terradot, L., Fischer, W., and Haas, R. (2009) Helicobacter pylori type IV secretion apparatus exploits 1 integrin in a novel RGD-independent manner. PLoS Pathog. 5, e1000684.

Fischer, W., Prassl, S., and Haas, R. (2009) Virulence mechanisms and persistence strategies of the human gastric pathogen Helicobacter pylori. In: Molecular Mechanisms of Bacterial Infection via the Gut, Curr. Topics Microbiol. Immunol. 337, C. Sasakawa, Ed., Springer Verlag, Berlin, Heidelberg; p. 129-171.

Kutter, S., Buhrdorf, R., Haas, J., Schneider-Brachert, W., Haas, R., and Fischer, W. (2008) Protein subassemblies of the Helicobacter pylori Cag type IV secretion system revealed by localization and interaction studies. J. Bacteriol. 190, 2161-2171.

Fischer, W., Karnholz, A., Jimenez-Soto, L.F., and Haas, R. (2008) Type IV secretion systems in Helicobacter pylori. In: Helicobacter pylori: Molecular Genetics and Cellular Biology; Y. Yamaoka, Ed., Caister Academic Press, Norfolk, UK; p. 115-136.

Sewald, X., Fischer, W., and Haas, R. (2008) Sticky socks: Helicobacter pylori VacA takes shape. Trends Microbiol. 16, 89-92.

Hare, S., Fischer, W., Williams, R., Terradot, L., Bayliss, R., Haas, R., and Waksman, G. (2007) Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase. EMBO J. 26, 4926-4934.

Pattis, I., Weiss, E., Laugks, R., Haas, R., and Fischer, W. (2007) The Helicobacter pylori CagF protein is a type IV secretion chaperone-like molecule that binds close to the C-terminal secretion signal of the CagA effector protein. Microbiology 153, 2896-2909.

Backert, S., and Fischer, W. (2007) Transport von Proteinen und DNA – Typ IV-Sekretion bei Gram-negativen Bakterien. Naturwiss. Rundschau 60, 10-17.

Torruellas Garcia, J., Ferracci, F., Jackson, M.W., Joseph, S., Pattis, I., Plano, L.R., Fischer, W., and Plano, G.V. (2006) Measurement of effector protein injection by type III and type IV secretion systems using a 13-residue phosphorylatable GSK tag. Infect. Immun. 74, 5645-5657.

Hohlfeld, S., Pattis, I., Püls, J., Plano, G.V., Haas, R., and Fischer, W. (2006) A C-terminal secretion signal is necessary, but not sufficient for type IV secretion of the Helicobacter pylori CagA protein. Mol. Microbiol. 59, 1624-1637.

Karnholz, A., Höfler, C., Odenbreit, S., Fischer, W., Hofreuter, D., and Haas, R. (2006) Functional and topological characterization of novel components of the comB DNA transformation competence system in Helicobacter pylori. J. Bacteriol. 188, 882-893.

Lytton, S.D., Fischer, W., Nagel, W., Haas, R., and Beck, F.X. (2005) Production of ammonium by Helicobacter pylori mediates occludin processing and disruption of tight junctions in CACO-2 cells. Microbiology 151, 3267-3276.

Rieder, G., Fischer, W., and Haas, R. (2005) Interaction of Helicobacter pylori with host cells: Function of secreted and translocated molecules. Curr. Opin. Microbiol. 8, 67-73.
Al-Ghoul, L., Wessler, S., Hundertmark, T., Krüger, S., Fischer, W., Wunder, C., Haas, R., Roessner, A., and Naumann, M. (2004) Analysis of the type IV secretion system-dependent cell motility of Helicobacter pylori-infected epithelial cells. Biochem. Biophys. Res. Commun. 322, 860-866.

Fischer, W., and Haas, R. (2004) The RecA protein of Helicobacter pylori requires a posttranslational modification for full activity. J. Bacteriol. 186, 777-784.

Gebert, B., Fischer, W., and Haas, R. (2004) The Helicobacter pylori vacuolating cytotoxin: from cellular vacuolation to immunosuppressive activities. Rev. Physiol. Biochem. Pharmacol. 152, 205-220.

Höfler, C., Fischer, W., Hofreuter, D., and Haas, R. (2004) Cryptic plasmids in Helicobacter pylori: putative functions in conjugative transfer and microcin production. Int. J. Med. Microbiol. 294, 141-148.

Fischer, W., Gebert, B., and Haas, R. (2004) Novel activities of the Helicobacter pylori vacuolating cytotoxin: from epithelial cells towards the immune system. Int. J. Med. Microbiol. 293, 539-547.

Aras, R.A., Fischer, W., Perez-Perez, G.I., Crosatti, M.L., Ando, T., Haas, R., and Blaser, M.J. (2003) Plasticity of repetitive DNA sequences within a bacterial (type IV) secretion system component. J. Exp. Med. 198, 1349-1360.

Gebert, B., Fischer, W., Weiss, E., Hoffmann, R., and Haas, R. (2003) Helicobacter pylori vacuolating cytotoxin inhibits T-lymphocyte activation. Science 301, 1099-1102.

Rohde, M., Püls, J., Buhrdorf, R., Fischer, W., and Haas, R. (2003) A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system. Mol. Microbiol. 49, 219-234.

Buhrdorf, R., Förster, C., Haas, R., and Fischer, W. (2003) Topological analysis of a putative virB8 homologue essential for the cag type IV secretion system in Helicobacter pylori. Int. J. Med. Microbiol. 293, 213-217.

Savvides, S.N., Yeo, H.-J., Beck, M.R., Bläsing, F., Lurz, R., Lanka, E., Buhrdorf, R., Fischer, W., Haas, R., and Waksman, G. (2003) VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion. EMBO J. 22, 1969-1980.

Kavermann, H., Burns, B.P., Angermüller, K., Odenbreit, S., Fischer, W., Melchers, K., and Haas, R. (2003) Identification and characterization of Helicobacter pylori genes essential for gastric colonization. J. Exp. Med. 197, 813-822.
Püls, J., Fischer, W., and Haas, R. (2002) Activation of Helicobacter pylori CagA by tyrosine phosphorylation is essential for dephosphorylation of host cell proteins in gastric epithelial cells. Mol. Microbiol. 43, 961-969.

Fischer, W., Haas, R., and Odenbreit, S. (2002) Type IV secretion systems in pathogenic bacteria. Int. J. Med. Microbiol. 292, 159-168.
Fischer, W., Püls, J., Buhrdorf, R., Gebert, B., Odenbreit, S., and Haas, R. (2001) Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol. Microbiol. 42, 1337-1348.

Fischer, W., Buhrdorf, R., Gerland, E., and Haas, R. (2001) Outer membrane targeting of passenger proteins by the vacuolating cytotoxin autotransporter of Helicobacter pylori. Infect. Immun. 69, 6769-6775.

Odenbreit, S., Gebert, B., Püls, J., Fischer, W., and Haas, R. (2001) Interaction of Helicobacter pylori with professional phagocytes: role of the cag pathogenicity island and translocation, phosphorylation and specific processing of CagA. Cellular Microbiol. 3, 21-31.

Fischer, W., Hofreuter, D., and Haas, R. (2001) Natural transformation, recombination and repair. In: Helicobacter pylori: Physiology and Genetics; H.L.T. Mobley, G.L. Mendz and S.L. Hazell, Eds., ASM Press, Washington, D.C., USA; p. 249-257.

Odenbreit, S., Püls, J., Sedlmaier, B., Gerland, E., Fischer, W., and Haas, R. (2000) Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287, 1497-1500.

Wessler, S., Höcker, M., Fischer, W., Wang, T.C., Rosewicz, S., Haas, R., Wiedenmann, B., Meyer, T.F., and Naumann, M. (2000) Helicobacter pylori activates the histidine decarboxylase promoter through a mitogen-activated protein kinase pathway independent of pathogenicity island-encoded virulence factors. J. Biol. Chem. 275, 3629-3636.

Fischer, W., and Haas, R. (2000) Helicobacter pylori vacuolating cytotoxin. In: Bacterial Protein Toxins; Handbook of Experimental Pharmacology, Vol. 145; K. Aktories, I. Just, Eds.; Springer-Verlag, Berlin / Heidelberg, Germany; p. 489-507.

1995  -  1999

Fischer, W., Schwan, D., Gerland, E., Erlenfeld, G.E., Odenbreit, S., and Haas, R. (1999) A plasmid-based vector system for the cloning and expression of Helicobacter pylori genes encoding outer membrane proteins. Mol. Gen. Genet. 262, 501-507.

Kahrs, A.F., Odenbreit, S., Schmitt, W., Heuermann, D., Meyer, T.F., and Haas, R. (1995) An improved TnMax mini-transposon system suitable for sequencing, shuttle mutagenesis and gene fusions. Gene 167, 53-57.

Schmitt, W., Odenbreit, S., Heuermann, D., and Haas, R. (1995) Cloning of the Helicobacter pylori recA gene and functional characterization of its product. Mol. Gen. Genet. 248, 563-572.

Schmitt, W., and Haas, R. (1994) Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with IgA protease type of exported protein. Mol. Microbiol. 12, 307-319.