English version
Sitemap | LMU | LMU-Portal


Forschung > Medizinische Mikrobiologie und Krankenhaushygiene > AG Haas Rainer > Publikationen > 

Publikationsliste (nur referierte Arbeiten)

2017

160.    Pick R, Stocker TJ, Salvermoser M, Begandt D, Montanez E, Wirth M, Harrison U, Khandoga AG, Coletti R, Weckbach LT, Brechtefeld D, Forné I, Haas R, Massberg S, Sperandio M, Walzog B. Coronin 1A - a novel player in integrin biology - controls neutrophil trafficking in innate immunity. Blood 2017 Jun 14. doi: 10.1182/blood-2016-11-749622. (2017)

159.    Zeitler AF, Moldovan A, Gerrer KH, Schriefer EM, Heesemann J, Haas R, Jiménez-Soto LJ. Host cell resistance to CagA translocation is as variable as Helicobacter pylori. Science Matters, accepted for publication, in press (2017)

158.    Harrison U, Fowora MA, Seriki AT, Loell E, Mueller S, Ugo-Ijeh M, Onyekwere CA, Lesi OA, Otegbayo JA, Akere A, Ndububa DA, Adekanle O, Anomneze E, Abdulkareem FB, Adeleye IA, Crispin A, Fischer W, Smith SI, Haas R. Helicobacter pylori strains from a Nigerian cohort show divergent antibiotic resistance rates and a uniform pathogenicity profile. PLoS One 2017 May 2;12(5):e0176454. doi: 10.1371/journal.pone.0176454. eCollection (2017).

157.    Bugaytsova JA, Björnham O, Chernov YA, Gideonsson P, Henriksson S, Mendez M, Sjöström R, Mahdavi J, Shevtsova A, Ilver D, Moonens K, Quintana-Hayashi MP, Moskalenko R, Aisenbrey C, Bylund G, Schmidt A, Åberg A, Brännström K, Königer V, Vikström S, Rakhimova L, Hofer A, Ögren J, Liu H, Goldman MD, Whitmire JM, Ådén J, Younson J, Kelly CG, Gilman RH, Chowdhury A, Mukhopadhyay AK, Nair GB, Papadakos KS, Martinez-Gonzalez B, Sgouras DN, Engstrand L, Unemo M, Danielsson D, Suerbaum S, Oscarson S, Morozova-Roche LA, Olofsson A, Gröbner G, Holgersson J, Esberg A, Strömberg N, Landström M, Eldridge AM, Chromy BA, Hansen LM, Solnick JV, Lindén SK, Haas R, Dubois A, Merrell DS, Schedin S, Remaut H, Arnqvist A, Berg DE, Borén T. Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence. Cell Host & Microbe, 8;21(3):376-389. (2017)

156.    Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang A, Kawakami N, Leliavski A, Uhl O, Chen C-S, Kraus K, Juan A, Hergenhan S, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H Scheiermann C. Lymphocyte circadian clocks control lymph node trafficking and adaptive immune responses. Immunity 2017 Jan 6. pii: S1074-7613(16)30517-9. doi: 10.1016/j.immuni.2016.12.011. [Epub ahead of print] (2017)

155.    Santos JC, Brianti MT, Almeida VR, Ortega MM, Fischer W, Haas R, Matheu A, Ribeiro ML. Helicobacter pylori infection modulates the expression of miRNAs associated with DNA mismatch repair pathway. Molecular Carcinogenesis, 56(4):1372-1379. doi: 10.1002/mc.22590. (2017)

 

2016

154.    Javaheri A, Kruse T, Moonens K, Asche I, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Königer V, Hauck CR, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Remaut H, Backert S, Singer BB and Gerhard M. Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. Nat Microbiol. 2016 Oct 17;2:16189. doi: 10.1038/nmicrobiol.2016.189. (2016)

153.    Königer V, Holsten L, Harrison U, Busch B, Loell E, Zhao Q, Bonsor DA, Roth A, Kengmo-Tchoupa A, Smith SI, Mueller S, Sundberg SJ, Zimmermann W, Fischer W, Hauck CR and Haas R. Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. Nature Microbiol., 17 OCTOBER 2016 | ARTICLE NUMBER: 16188 | DOI: 10.1038/NMICROBIOL.2016.188. (2016)

152.    Kurz ARM, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, Gouveia G, Nussbaum CF, Immler R, Wiessner JR, Margraf A, Lim D-S, Walzog B, S Dietzel S, Moser M, Klein C, Vestweber D, Haas R Catz SD, and Sperandio M. MST-1 dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. J Clin Invest. Nov 1;126(11):4125-4139. doi: 10.1172/JCI87043. (2016)

151.    Utsch C, Haas R. VacA's Induction of VacA-Containing Vacuoles (VCVs) and Their Immunomodulatory Activities on Human T Cells. Toxins (Basel). 2016 Jun 18;8(6). doi: 10.3390/toxins8060190. (2016)

150.    Zeitler AF, Gerrer KH, Haas R, Jiménez-Soto LF2. Optimized semi-quantitative blot analysis in infection assays using the Stain-Free technology. J Microbiol Methods. 2016 Jul;126:38-41. doi: 10.1016/j.mimet.2016.04.016. (2016)

149.    Schindele F, Weiss E, Haas R and Fischer W. Quantitative analysis of CagA type IV secretion by Helicobacter pylori reveals substrate recognition and translocation requirements. Manuscript submitted Molecular Microbiology. 100(1):188-203 (2016).

148.    Jiménez-Soto L.J. and Haas R. The CagA toxin of Helicobacter pylori: abundant production but relatively low amount translocated. Sci Rep. (2016) Mar 17;6:23227. doi: 10.1038/srep23227. (2016)


2015

147.    Klapproth S, Moretti FA, Zeiler M, Ruppert R, Breithaupt U, Mueller S, Haas R, Mann M, Sperandio M, Fässler R, and Moser M. Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice. Blood, 26(24):2592-2600. (2015)

146.    Rojas-Rengifo DF, Jaramillo CA, Haas R, Jiménez-Soto LF. Detection of cytoplasmic proteins from Helicobacter pylori in Colony Lift Immunoassay. J Microbiol Methods. 119:145-6. (2015)

145.    Meyer C, Hoffmann C, Haas R, Schubert S. The role of the galU gene of uropathogenic Escherichia coli in modulating macrophage TNF-α response. Int J Med Microbiol. 305, (8), 893–901. (2015) 

144.    Beate Kern, Utkarsh Jain, Ciara Utsch, Andreas Otto, Benjamin Busch, Luisa Jimenez-Soto, Dörte Becher and Rainer Haas, Characterization of Helicobacter pylori VacA-containing vacuoles (VCVs), VacA intracellular trafficking and interference with calcium signalling in T-lymphocytes. Submitted (2015)

143.    Daniel A. Bonsor, Kieu T. Pham, Robert Beadenkopf, Kay Diederichs, Rainer Haas, Dorothy Beckett, Wolfgang Fischer, Eric J. Sundberg, Integrin engagement by the helical RDG motif of the Helicobacter pylori CagL protein is regulated by pH-induced displacement of a neighboring helix. J Biol Chem, 290:12929-12940 (2015)

142.    Benjamin Busch, Ramona Weimer, Christine Woischke, Wolfgang Fischer, Rainer Haas, Helicobacter pylori interferes with leukocyte migration via the outer membrane protein HopQ and via CagA translocation. Int J Med Microbiol, 305:355-364, (2015)

141.    Birgit Keller, Melanie Mühlenkamp, Eva Deuschle, Alexandra Siegried, Sara Mössner, Jessica Schade, Tanja Griesinger, Nenad Katava, Christina Braunsdorf, Birgit Fehrenbacher, Luisa F. Jimenez-Soto, Martin Schaller, Rainer Haas, Harald Genth, Saverio F. Retta, Hannelore Meyer, Ralph T. Böttcher, Roy Zent, Monika Schütz, Inge B. Autenrieth and Erwin Bohn. Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells. Cell Microbiol, (2015)


2014

140.    Wolfgang Fischer, Ute Breithaupt, Beate Kern, Stella I Smith, Carolin Spicher and Rainer Haas, A comprehensive analysis of Helicobacter  pylori plasticity zones reveals that they are integrating conjugative elements with intermediate integration specificity. BMC Genomics, 15:310 (2014)


2013

139.    Rivera-Ordaz A, Bracher S, Sarrach S, Li Z,  Shi L, Quick M, Hilger D, Haas R, Jung H. The Sodium/Proline Transporter PutP of Helicobacter pylori. PLoS One 8(12):e83576. doi:10.1371/journal.pone.0083576 (2013)

138.    Bonsor DA, Weiss E, Iosub-Amir A, Reingewertz TH, Chen TW, Haas R, Friedler A, Fischer W, Sundberg EJ. Characterization of the Translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF. J Biol Chem. 288:32897-909. (2013)

137.    Jiménez-Soto LF, Clausen S, Sprenger A, Ertl C, Haas R., Dynamics of the Cag-type IV secretion system of Helicobacter pylori as studied by bacterial co-infections, Cell Microbiol, 15:1924-1937 (2013)

136.    Belogolova E, Bauer B, Pompaiah M, Asakura H, Brinkman V, Ertl C, Bartfeld S, Nechitaylo TY, Haas R, Machuy N, Salama N, Churin Y, Meyer TF.Helicobacter pylori outer membrane protein HopQ identified as a novel T4SS-associated virulence factor. Cell Microbiol, 15:1896-912 (2013)


2012

135.     Stefanie Rohrer, Lea Holsten, Evelyn Weiss, Mohammed Benghezal, Wolfgang Fischer, Rainer Haas, Multiple pathways of plasmid DNA transfer in Helicobacter pylori, PLoS One, 7: e45623 (2012)

134.    Burcu Kaplan-Türköz, Luisa F. Jimenez Soto, Cyril Dian, Claudia Ertl, Han Remaut, Arthur Louche, Tommaso Tosi, Rainer Haas, and Laurent Terradot, Structural insights into helicobacter pylori oncoprotein CagA interaction with β1 integrin, PNAS, 109:14640-5 (2012)
2012

133.    Talarico S, Whitefield SE, Fero J, Haas R, Salama NR, Regulation of Helicobacter pylori adherence by gene conversion, Mol Microbiol, in press (2012)

132.    Pham KT, Weiss E, Jimenez Soto LF, Breithaupt U, Haas R, Fischer W, CagI Is an essential component of the Helicobacter pylori Cag Type IV Secretion System and forms a complex with CagL, PLoS ONE, 7:-e35341 (2012)

131.    Jiménez Soto LF, Rohrer S, Jain U, Ertl C, Sewald X, Haas R., Effects of cholesterol on Helicobacter pylori growth and virulence properties in vitro. Helicobacter, 17:133-139 (2012)


2011

130.    Smith SI, Fowora MA, Otegbayo JA, Abdulkareem FM, Omonigbehin EA, Adegboyega A, Contreras M, Haas R.,Comparison of PCR with other diagnostic techniques for the detection of H. pylori infection in patients presenting with gastroduodenal symptons in Nigeria. Int J Mol Epidemiol Genet, 2:178-84 (2011)

129. Ishijima, N., Suzuki, M., Ashida, H., Ichikawa, Y., Kanegae, Y., Saito, I., Bóren, T., Haas, R., Sasakawa, C., Mimuro, H., BabA-mediated adherence is a potentiator of the Helicobacter pylori Type IV secretion system activity. JBC 286: 25256-64 (2011)


2010

128. Sewald X, Jiménez-Soto L, Haas R. PKC-dependent endocytosis of the Helicobacter pylori vacuolating cytotoxin in primary T lymphocytes. Cell Microbiol. 2010 Nov 17. doi: 10.1111/j.1462-5822.2010.01551.x. (2010)

127. Smith SI, Omonigbehin EA, Goodluck HA, Abdulkareem FB, Onyekwere CA, Agomo C, Ndububa DA, Fowora MA, Otegbayo JA, Contreras M, Haas R, Rieder G. Diagnostic methods for the detection of Helicobacter pylori in Nigeria. Trop Gastroenterol. 31(2):113-5. (2010)

126. Olofsson A, Vallström A, Petzold K, Tegtmeyer N, Schleucher J, Carlsson S, Haas R, Backert S, Wai SN, Gröbner G, Arnqvist A. Biochemical and functional characterization of Helicobacter pylori vesicles. Mol Microbiol. 77(6):1539-55 (2010)

125. Farnbacher M, Jahns T, Willrodt D, Daniel R, Haas R, Goesmann A, Kurtz S, Rieder G. Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8. BMC Genomics 11:335-357 (2010)

124. Fischer W, Windhager L, Rohrer S, Zeiller M, Karnholz A, Hoffmann R, Zimmer R, Haas R. Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res 38(18):6089-6101 (2010)

123. Ding SZ, Fischer W, Kaparakis-Liaskos M, Liechti G, Merrell DS, Grant PA, Ferrero RL, Crowe SE, Haas R, Hatakeyama M, Goldberg JB. Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. PLoS One. 1;5(4):e9875 (2010)


2009

122. Magalhães A, Gomes J, Ismail MN, Haslam SM, Mendes N, Osório H, David L, Lependu J, Haas R, Dell A, Borén T, Reis CA. Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa. Glycobiology 19(12):1525-36 (2009)

121. Jimenez-Soto, L.F., Sewald, X., Kutter, S., Ertl, C., Weiss, E., Kapp, U., Rohde, M., Pirch, T., Jung, K., Terradot, J., Fischer, W. and Haas, R.,  Helicobacter pylori Type IV secretion apparatus  exploits β1Integrin in a novel RGD-independent manner.  PLoS Pathog, 5:e1000684 (2009)

120. Odenbreit, S., Swoboda, K., Barwig, I., Ruhl, S., Borén, T., Koletzko, S. and Haas, R., Outer memebrane protein (OMP) expression profile in Helicobacter pylori clinical isolates. Infect Immun, in press (2009)

119. Sewald, X. and Haas, R., Das multifunktionelle Toxin VacA von Helicobacter pylori.  BIOspektrum, 02.09, 15. Jhrg. (2009)

118. Wiedemann,T.,  Loell, E.,  Mueller, S., Stoeckelhuber, M., Stolte, M., Haas, R. and Rieder, G., Helicobacter pylori cag-Pathogenicity Island-dependent early immunological response triggers later precancerous gastric changes in mongolian gerbils. PLoS ONE,  4: e4754 (2009)

117. Fischer, W., Prassl, S., and Haas, R., Virulence mechanisms and persistence strategies of the human gastric pathogen Helicobacter pylori. Current Topics of Microbiology and Immunology, in press (2009)

116. Tuo, B., Wen, G., Gebert-Vogl, B., Haas, R., Manns, M. and Seidler, U., Helicobacter pylori vacuolating cytotoxin inhibits duodenal HCO3- secretion by a histamine-dependent mechanism in mice.  J Inf Disease, 199:505–512 (2008)


2008

115.    Azevedo, M., Eriksson, S., Mendes, N., Serpa, J., Figueiredo, C., Resendek LP., Ruvoën-Clouet, N.,  Haas, R., Borén, T., Le Pendu, J. and David, L., Infection by Helicobacter pylori expressing the BabA adhesin is influenced by the secretor phenotype. J Pathology, 215:308-316 (2008)

114.    Kutter, S., Buhrdorf, R., Haas, J., Schneider-Brachert, W., Haas, R. and Fischer, W., Protein subassemblies of the Helicobacter pylori Cag Type IV Secretion System revealed by localization and interaction studies. J Bacteriol, 19:2161-71 (2008)

113.     Sewald, X., Fischer, W. and Haas, R., Sticky socks: Helicobacter pylori VacA takes shape. Trends in Microbiology, 16:88-92 (2008)

112.     Fischer, W., Karnholz, A., Jimenez-Soto, L.F. and Haas, R., Type IV secretion systems in Helicobacter pylori. Molec. Genetics of Helicobacter, Horizon Scientific Press (2008)

111.     Sewald, X., Gebert-Vogl, B., Prassl, S., Barwig, I., Weiss, E., Fabbri, M., Osicka, R., Schiemann, M., Busch, D. H., Semmrich, M., Holzmann, B., Sebo, P. and  Haas, R., Integrin subunit CD18 is the T-Lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin. Cell Host & Microbe, 3:20-29 (2008)


2007

110.    Hare, S., Fischer, W., Williams, R., Bayliss, R., Haas, R., and Waksman, G., Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase. The EMBO J. 26:4926-4934. (2007)

109.    Mimuro,H., Suzuki,T., Nagai, S., Rieder, G., Suzuki, M., Nagai, T., Fujita, Y.,  Nagamatsu, K., Ishijima, N., Koyasu, S., Haas, R., and Sasakawa, C. Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach. Cell Host & Microbe, 2:250-263 (2007)

108.    Hoffelner, H., Rieder, G., and Haas, R., Helicobacter pylori vaccine development: optimization of strategies and importance of challenging strain and animal model. Int J Med Microbiol, 298:151-159 (2007)

107.    Rieder, G., Karnholz, A., Stoeckelhuber, M., Merchant, J.L., and Haas, R. Helicobacter pylori infection causes chronic pancreatitis in Mongolian gerbils. WJG, 13:3939-3947 (2007)

106.    Pattis, I., Weiss, E., Laugks, R., Haas, R. and Fischer, W. The Helicobacter pylori CagF protein is a type IV secretion chaperone-like molecule that binds close to the C-terminal secretion signal of the CagA effector protein. Microbiology, 153:2896-2909 (2007)

105.    Lu, H., Wu, J.Y., Beswick, E.J., Ohno, T., Odenbreit, S. and Haas, R., Reyes, V.E., Kita, M., Graham, D.Y., Yamaoka, Y. Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains. J Biol Chem. 282:6242-54. (2007)
   
104.    Fujimoto, S., Olaniyi Ojo, O., Arnqvist, A., Wu, J.Y., Odenbreit, S., Haas, R., Graham, D.Y. and Yamaoka, Y., Helicobacter pylori BabA expression, gastric mucosal injury, and clinical outcome. Clin Gastroenterol Hepatol. 1:49-58. (2007).

2006

103.    Aspholm, M., Olfat, F.O., Nordén, J., Sondén, B., Lundberg, C., Sjöström, R., ltraja, S., Odenbreit, S., Haas, R., Wadström, T., Engstrand, L., Teneberg, S., Arnqvist,A., and Borén, T., SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans. PLoS Pathog.; 2:e110 (2006)

102.    Stähler, F.N., Odenbreit, S. Haas, R., Wilrich, J., van Vliet, A.H.M., Kusters, J.G., Kist, M. and Bereswill, S., The novel Helicobacter pylori CznABC metal efflux pump is required for cadmium, zinc and nickel resistance, for urease modulation and for gastric colonization. Infect Immun. 74:3845-3852 (2006)

101.    Odenbreit, S., Linder, S., Gebert-Vogl, B., Rieder, G., Moran, A.C. and Haas R., Interleukin-6 induction by Helicobacter pylori in human macrophages is dependent on phagocytosis. Helicobacter 11:196-207 (2006)

100.    Hohlfeld, S., Pattis, I., Püls, J., Plano, G.V., Haas, R. and Fischer, W., A C-terminal translocation signal is necessary, but not sufficient for type IV secretion of the Helicobacter pylori CagA protein. Mol Microbiol 59:1624-37 (2006)

99.    Yamaoka Y, Ojo, O., Fujimoto, S., Odenbreit, S.,  Haas, R., Gutierrez, O., El-Zimaity, H., Reddy, R., Arnqvist, A., Graham, D.Y., Helicobacter pylori Outer Membrane Proteins and Gastroduodenal Disease. Gut, 55:775–781 (2006)

98.    Karnholz, A., Hoefler, C., Odenbreit, S., Fischer, W., Hofreuter, D., Haas, R., Functional and topological characterisation of novel components of the comB DNA transformation competence system in Helicobacter pylori. J Bacteriol 188:882-93 (2006)

2005

97.    Lytton, D.S., Fischer, W., Nagel, W., Haas, R., Beck, F.X., Production of ammonium by Helicobacter pylori mediates occludin processing and disruption of tight junctions in Caco-2 cells. Microbiology 151:3267-3276 (2005)

96.    Rieder, G., Merchant, J.L., Haas, R., Helicobacter pylori cag-Type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian Gerbil. Gastroenterology 128:1229-1242 (2005)

95.    Rieder, G., Fischer, W., Haas, R., Interaction of Helicobacter pylori with host cells: Function of secreted and translocated molecules. Curr Opin Microbiol 8:67-73 (2005)


2004

94.     Hoffelner, H., Haas, R., Recombinant bacterial ghosts: versatile targeting vehicles and promising vaccine candidates. Int J Med Microbiol 294:303-311 (2004)

93.    Höfler, C., Fischer, W., Hofreuter, D., Haas, R., Cryptic plasmids in Helicobacter pylori: putative functions in conjugative transfer and microcin production. Int J Med Microbiol 294:141-148 (2004)

92.    Gebert, B., Fischer, W., Haas, R., The Helicobacter pylori vacuolating cytotoxin: from cellular vacuolation to immunosuppressive activities. Rev Physiol Biochem Pharmacol 152:205-220 (2004)

91.    Al-Ghoul, L., Wessler, S., Hundertmark, T., Krüger, S., Fischer, W., Wunder, C., Haas, R., Roessner, A., Naumann, M., Analysis of the type IV secretion system-dependent cell motility of Helicobacter pylori-infected epithelial cells. Biochem Bioph Res Co 322:860-866 (2004)

90.    Kudo, T., Nurgalieva, Z.Z., Conner, M.E., Crawford, S., Odenbreit, S., Haas, R., Graham D.Y., and Yamaoka, Y., Correlation between Helicobacter pylori OipA Protein expression and oipA Gene Switch Status. J Clin Microbiol 42:2279-2281 (2004)

89.    Loewen, P.C., Carpena, X., Perez-Luque, R., Rovira, C., Haas, R., Odenbreit, S., Nicholls, P., and Fita, I., Structure of Helicobacter pylori catalase, with and without formic acid bound, at 1.6 A resolution. Biochemistry 43:3089-3103 (2004)

88.    Fischer, W., and Haas, R., The RecA protein of Helicobacter pylori requires a posttranslational modification for full activity. J Bacteriol 186:774-784 (2004)

87.    Fischer, W., Gebert, B., and Haas, R., Novel activities of the Helicobacter pylori vacuolating cytotoxin: from epithelial cells towards the immune system. Int J Med Mol 293:539-547 (2004)


2003

86.    Aras, R., Fischer, W., Crosatti, M.L., Perez-Perez, G.I., Ando, T., Haas, R., and Blaser, M., Plasticity of repetitive DNA sequences in a bacterial (type IV) secretion system component. J Exp Med, 198:1349-1360 (2003)

85.    Gebert, B., Fischer, W., Weiss, E., Hoffmann, R. and Haas, R., Helicobacter pylori vacuolating cytotoxin inhibits T–Lymphocyte activation. Science, 301:1099-1102 (2003)

84.     Panthel, K., Dietz, P., Haas, R. and Beier, D., Two-component systems of Helicobacter pylori contribute to virulence in a mouse infection model. Infect Immun, 71:5381-5385 (2003)

83.     Savvides S.N., Yeo H.J, Beck M.R., Blaesing F., Lurz R., Lanka E., Buhrdorf R., Fischer W., Haas R., Waksman G. Structural and functional investigations of the traffic ATPase of Helicobacter pylori provide insights into the role of VirB11 ATPases in bacterial type IV secretion. EMBO J, 22:1969-1980 (2003)

82.    Rohde, M., Püls, J., Buhrdorf, R., Fischer, W., Haas, R. A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system. Mol Microbiol 49:219-234 (2003)

81.    Buhrdorf, R., Förster, C., Haas, R., and Fischer, W., Topological analysis of a putative virB8 homologue essential for the cag type IV secretion system in Helicobacter pylori. Int J Med Microbiol, 293:213-217 (2003)

80.    Hofreuter, D., Karnholz, A., and Haas, R., Topology and membrane interaction of Helicobacter pylori ComB proteins involved in natural transformation competence. Int J Med Microbiol, 293:153-165 (2003)

79.    Kavermann, H., Burns, B. P., Angermüller, K., Odenbreit, S., Fischer, W., Melchers, K., and Haas, R., Identification of Helicobacter pylori genes essential for gastric colonization. J Exp Med, 197:813-822 (2003)

78.    Panthel, K., Faller, G., and Haas, R., Colonization of C57BL/6J and BALB/c wild-type and knockout mice with Helicobacter pylori: Effect of vaccination and implications for innate and acquired immunity. Infect Immun, 71:794-800 (2003)

77.    Panthel, K., Jechlinger, W., Matis, A., Rohde, M., Szostak, M., Lubitz, W., and Haas, R., Generation of Helicobacter pylori ghosts by PhiX protein E-mediated inactivation and their evaluation as vaccine candidates. Infect Immun, 71:109-116 (2003)


2002

76.    Mimuro, H., Suzuki, T., Tanaka, J., Asahi, M., Haas, R., and Sasakawa, C., Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol Cell, 10:745-755 (2002)

75.    Odenbreit, S., Kavermann, H., Püls, J. and Haas, R., CagA tyrosine phosphorylation and interleukin-8 induction by Helicobacter pylori are independent from AlpAB, HopZ and Bab-group outer membrane proteins. Int J Med Microbiol, 292:257-266 (2002)

74.    Odenbreit, S., Faller, G., and Haas, R., Role of the AlpAB proteins and lipopolysaccharide in adhesion of Helicobacter pylori to human gastric tissue. Int J Med Microbiol, 292:247-256 (2002)

73.    Fischer, W., Haas, R., and Odenbreit, S., Type IV secretion systems in pathogenic bacteria. Int J Med Microbiol, 292:159-168 (2002)

72.    Waidner, B., Greiner, S., Odenbreit, S., Kavermann, H., Velayudhan, J., Stähler, F., Bissé, E., van Vliet, A.H.M., Andrews, S.C., Kusters, J.G., Kelly, D.J., Haas, R., Kist, M., Bereswil, S., Essential role of Ferritin Pfr in Helicobacter pylori iron metabolism and gastric colonization. Infect Immun, 70:3923-3929 (2002)

71.    Yamaoka, Y., Souchek, J., Odenbreit, S., Haas, R., Arnqvist, A., Borén, T., Kodama, T., Osato, M., Gutierrez, O., Kim, J., and Graham, D.: Discrimination between Cases of Duodenal Ulcer and Gastritis on the Basis of Putative Virulence Factors of Helicobacter pylori. J Clin Microbiol, 40:2244-2246 (2002)

70.    Hofreuter, D., and Haas, R. Characterization of Two Cryptic Helicobacter pylori Plasmids: a Putative Source for Horizontal Gene Transfer and Gene Shuffling. J Bacteriol 184:2755-2766 (2002)

69.    Hofreuter, D., and Haas, R. Natural transformation in Helicobacter pylori: DNA transport in an unexpected way. TIM, 10:162 (2002)

68.    Püls, J., Fischer, W., and Haas, R., Activation of Helicobacter pylori CagA by tyrosine phosphorylation is essential for dephosphorylation of host cell proteins in gastric epithelial cells. Mol Microbiol, 43:961–969 (2002)

67.    Odenbreit S., and Haas, R., Helicobacter pylori – impact of gene transfer and the role of the cag pathogenicity island for host adaptation and virulence. Hacker, J., Kaper, J.B.: Springer-Verlag, Berlin: S 1–17 (2002)


2001

66.    Rüssmann, H., Adler, K., Haas, R., Gebert, B., Koletzko, S. and Heesemann, J.: Rapid and accurate determination of genotypic clarithromycin resistance in cultured Helicobacter pylori by Fluorescent In Situ Hybridization. J Clin Microbiol, 39:4142-4144 (2001)

65.    Fischer, W., Püls, J., Buhrdorf, R., Gebert, B., Odenbreit, S., and Haas, R., Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol Microbiol, 42:1337-1348 (2001)

64.    Haas, R., Burns, B.P. and Asahi, M., Pathogenesis of Helicobacter pylori. The year in Helicobacter 2001. Lippincott Williams & Wilkins Science Publishers, 17: S1–S5 (2001)

63.    Fischer, W., Buhrdorf, R., Gerland, E., and Haas, R., Outer membrane targeting of passenger proteins by the vacuolating cytotoxin autotransporter of Helicobacter pylori. Infect Immun, 69:6769-6775 (2001)

62.    Hofreuter, D., Odenbreit, S., and Haas, R., Natural transformation competence in Helicobacter pylori is mediated by the basic components of a type IV secretion system. Mol Microbiol, 41:379-391 (2001)

61.    Fischer, W., Hofreuter, D. and Haas, R., Natural transformation, recombination and repair. Helicobacter pylori: Physiology and Genetics. H.L.T. Mobley, G.L. Mendz and S. Hazell (eds). ASM  Press, Washington DC pp. 249-257 (2001)

60.    Assmann, I.A., Enders, G.A., Püls, J., Rieder, G., Haas, R. and Hatz, A., Role of virulence factors, cell components and adhesion in Helicobacter pylori-mediated iNOS induction in murine macrophages. FEMS Immunol Med Microbiol, 30: 133-138 (2001)

59.     Trebesius, K., Adler, K., Vieth, M., Stolte, M., and Haas, R., Specific detection and prevalence of Helicobacter heilmannii-like organisms in the human gastric mucosa by fluorescent In situ hybridization and partial 16S ribosomal DNA sequencing. J Clin Microbiol, 39:1510-1516 (2001)

58.    Gerhard, M., Hirno, S., Wadström, T., Miller-Podraza, H., Teneberg, S., Karlsson, K.-A., Appelmelk, B., Odenbreit, S., Haas, R., Arnquvist, A., and Borén, T., Helicobacter pylori, an adherent pain in the stomach. Helicobacter pylori: Molecular and Cellular Biology. M. Achtman, S. Suerbaum (ed), Wymondham, UK: Horizon Scientific Press, pp. 185-206 (2001)

57.    Odenbreit, S., Gebert, B., Püls, J., Fischer, W., and Haas, R., Interaction of Helicobacter pylori with professional phagocytes: role of the cag pathogenicity island and translocation, phosphorylation and specific processing of CagA. Cellular Microbiology, 3:21-31 (2001)


2000

56.    Haas, R. Molekulare Infektionsbiologie, Eds, J. Hacker, J. Heesemann, M. Hensel, R. Haas, J. Reidl, Springer Verlag, (2000)

55.    Hofreuter, D., Odenbreit, S., Püls, J., Schwan, D., and Haas, R.,
Genetic competence in Helicobacter pylori: mechanisms and biological implications. Res Microbiol, 151:487-491 (2000)

54.    Wessler, S., Höcker, M., Fischer, W., Wang, T.C., Rosewicz, S., Haas, R., Wiedenmann, B., Meyer, T.F. and Naumann, M., Helicobacter pylori activates the histidine decarboxylase promoter through a mitogen-activated protein kinase pathway independent of pathogenicity island-encoded virulence factors. J Biol Chem, 275:3629-3636 (2000)

53.    Trebesius, K.-H., Panthel, K., Strobel, S., Vogt, K., Faller, G., Kirchner, T., Kist, M., Heesemann, J., and Haas, R., Rapid and specific detection of Helicobacter pylori clarithromycin resistance in gastric tissue by fluorescent in situ hybridization. Gut, 46:608-614 (2000)

52.    Odenbreit, S., Püls, J., Sedlmaier, B., Gerland, E., Fischer, W. and Haas, R., Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science, 287:1497-1500 (2000)

1999

51.    Naumann, M., Weßler, S., Bartsch, C., Wieland, B., Covacci, A., Haas, R., and Meyer, T.F., Activation of activator protein 1 and stress response kinases in gastric cells colonized by Helicobacter pylori encoding the cag pathogenicity island. J Biol Chem, 274: 31655-31662 (1999)

50.    Herrmann, L., Schwan, D., Garner, R., Mobley, H.L.T., Haas, R., Schäfer, K.P. and Melchers K. Helicobacter pylori cadA encodes an essential  Cd(II)-Zn(II)-Co(II) resistance factor influencing urease activity. Mol Microbiol, 33:524-537 (1999)

49.    Fischer, W., Schwan, D., Gerland, E., Erlenfeld, G.E., Odenbreit, S. and Haas, R., A plasmid-based vector system for cloning and expression of Helicobacter pylori genes encoding outer membrane proteins. Mol Gen Genet, 262:501-507 (1999)
48.    Fischer, W. and Haas, R., Helicobacter pylori vacuolating cytotoxin. Handbook of Experimental Pharmacology, 21:489-507, Springer Verlag, Berlin (1999)

47.    Odenbreit, S. Till, M., Hofreuter, D. and Haas, R., Genetic and functional characterization of the alpAB gene locus essential for adhesion of Helicobacter pylori to human gastric tissue. Mol Microbiol 31:1537-1548 (1999)


1998

46.    Melchers, K., Herrmann, L., Mauch, F., Bayle, D., Heuermann, D., Weitzenegger, T., Schuhmacher, A., Sachs, G., Haas, R., Bode, G., Bensch, K., Schäfer, K., Properties and function of the P type Ion pumps cloned from Helicobacter pylori. Actas Physiol Scand, 163: Suppl. 643,123-135 (1998)

45.    Hofreuter , D. Odenbreit, S., Henke, G. and Haas, R., Natural competence for DNA transformation in Helicobacter pylori: identification and genetic characterization of the comB locus. Mol Microbiol, 28:1027-1038 (1998)

44.    Corthésy-Theulaz, IE, Hopkins, S., Bachmann, D., Saldinger, PF, Porta, N, Haas, R., Zheng-Xin, Y., Meyer, T., Bouzourène, H., Blum, AL and Kraehenbuhl, JP., Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoPc expressing urease A and B subunits. Infect Immun, 66:581-586 (1998)

43.    Bereswill, S., Fassbinder, F., Volzing, C., Covacci, A., Haas, R. and Kist M., Hemolytic properties and riboflavin synthesis of Helicobacter pylori: cloning and functional characterization of the ribA gene encoding GTP- cyclohydrolase II that confers hemolytic activity to Escherichia coli. Med Microbiol Immunol (Berl), 186:177-187 (1998)

42.    Gomez-Duarte,, O.G., Lucas, B., Yan, ZX., Panthel, K., Haas, R. and Meyer T.F., Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B. Vaccine, 16:460-471(1998)

41.    Heuermann, D. and Haas, R., A stable shuttle vector system for efficient genetic complementation of Helicobacter pylori strains by transformation and conjugation. Mol Gen Genet,  257:519-528 (1998)


1997

40.    Bereswill, S., Fassbinder, F., Völzing, C., Haas, R., Reuter, K., Ficner, R. and Kist, M., Cloning and functional characterization of the genes encoding 3-dehydroquinate synthase (aroB) and tRNA-guanine transglycosylase (tgt) from Helicobacter pylori. Med Microbiol Immunol, 186:125-134 (1997)

39.    Haas, R. and Meyer, T.F., Vaccine development against Helicobacter pylori infections. Biologicals, 25:175-177 (1997)

38.    Haas, R., Strategien zur Entwicklung eines Impfstoffs gegen Helicobacter pylori. Die Gelben Hefte Jg. XXXVII (1) 8-14 (1997)

37.    Eck, M., Schmaußer, B., Haas, R., Greiner, A., Czub, S., and Müller-Hermelink, H.K. MALT-type lymphoma of the stomach is associated with Helicobacter pylori strains expressing the CagA protein. Gastroenterology, 112:1482-1486 (1997)

36.    Odenbreit, S., Wieland, B. and Haas, R., Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain. J Bacteriol, 178: 6960-6967 (1996)

35.     Odenbreit, S., Till, M. and Haas, R., Optimised BlaM- transposon shuttle mutagenesis of Helicobacter pylori allows the identification of novel genetic loci involved in bacterial virulence. Mol Microbiol, 20:361-373 (1996)

34.    Kahrs, A.F., Odenbreit, S., Schmitt, W., Heuermann, D. and Haas, R., An improved TnMax mini-transposon system suitable for sequencing, shuttle mutagenesis and gene fusions. Gene, 167:53-57 (1995)

33.    Heuermann, D. and Haas, R., Genetic organization of a small cryptic plasmid of Helicobacter pylori. Gene, 165:17-24 (1995)

32.     Schmitt, W., Odenbreit, S., Heuermann, D., and Haas, R., Cloning of the Helicobacter pylori recA gene and functional characterization of its product. Mol Gen Genet, 248:563-572 (1995)

31.     Corthésy-Theulaz, I., Porta, N., Glauser, M., Saraga, E., Vaney, A.-C., Haas, R., Kraehenbuhl, J.-P., Blum, A.L., and Michetti, P., Oral immunization with Helicobacter pylori urease B as a treatment against Helicobacter infection. Gastroenterology, 109:115-121 (1995)

30.    Haas, R., Mikrobiologie, Pathogenität und molekulare Mechanismen der Virulenz von Helicobacter pylori. Bio Spectrum, 3:35-40 (1995)

29.    Michetti, P. and Haas, R., Steps towards a vaccine. In: The year of Helicobacter 1994. Current Opinion in Gastroenterology, 53-57 (1994)

28.    Michetti, P., Corthésy-Theulaz, I., Davin, C., Haas, R., Vaney, A.-C., Heitz, M., Bille, J., Kraehenbuhl, J.-P., Saraga, E., and Blum, A.L., Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology, 107:1001-1011 (1994)

27.    Schmitt,W., and Haas, R., Genetic analysis of the Helicobacter pylori vacuolating  cytotoxin: structural similarites with the IgA protease type of exported protein. Mol Microbiol, 12:307-319 (1994)

26.    Haas, R., Leying, H., van Putten, J.P.M., Meyer, T.F., Geis, G., Suerbaum, S. and Opferkuch, W., Cloning of a Helicobacter pylori flagellin gene and construction of a non-flagellated mutant by transformation-mediated allelic exchange. In: Basic and Clinical Aspects of Helicobacter pylori Infection. G. Gasberrini and S. Pretolani (eds). 183-188 (1994)

25.    Tonjum, T. and Haas, R., Identification of Actinobacillus actinomycetemcomitans using leukotoxin gene-specific hybridization and polymerase chain reaction assays. J Clin Microbiol, 31:1856-1859 (1993)

24.     Haas, R., Meyer, T.F. and van Putten, J.P.M., Aflagellated mutants of Helicobacter pylori  generated by genetic transformation of naturally competent strains using shuttle mutagenesis. Mol Microbiol, 8:753-760 (1993)

23.    Haas, R., Kahrs, A.F. Facius, D., Allmeier, H., Schmitt, R. and Meyer, T.F., TnMax - a versatile mini-transposon for the analysis of cloned genes and shuttle mutagenesis. Gene, 130:23-31 (1993)

22.    Rudel, T., van Putten, J.P.M., Gibbs, C. P., Haas, R. and Meyer, T.F., Interaction of two variable proteins (PilE and PilC) required for pilus-mediated adherence of Neisseria  gonorrhoeae to human epithelial cells. Mol  Microbiol, 6:3439-3450 (1992)

21.    Hoyne, P.A., Haas, R., Meyer, T.F. and Elleman, T.C., Production of Neisseria gonorrhoeae  pili (fimbriae) in Pseudomonas aeruginosa. J Bacteriol, 174:7321-7327 (1992)

20.    Leying, H., Suerbaum, S., Geis, G. and Haas, R., Cloning and genetic characterization of a Helicobacter pylori flagellin gene. Mol Microbiol, 6:2863-2874 (1992)

19.    Haas, R., Veit, S., and Meyer, T.F., Silent pilin genes of Neisseria gonorrhoeae MS11 and the occurence of related hypervariant sequences among other gonococcal isolates. Mol Microbiol, 6:197-208 (1992)

18.    Meyer, T.F., Frosch, M., Gibbs,  C.P., Haas, R., Halter, R., Pohlner J. and van Putten, J.P.M., Virulenzmechanismen und Antigenvariation bei pathogenen Neisserien. Nova Acta Leopoldina NF 66, 279:187-200 (1991)

17.    Manning, P.A., Kaufmann, A., Roll, U., Pohlner, J., Meyer, T.F. and Haas, R., L-pilin variants of Neisseria gonorrhoeae. Mol Microbiol, 5:917-926 (1991)

16.    Haas, R., Facius, D., Gibbs, C., Rudel, T., van Putten, J.P.M. and Meyer, T.F., Pilin variation in Neisseria gonorrhoeae and modulation of cellular adherence. In Achtman, M. (ed.), Proceedings of the 7th International Pathogenic Neisseria Conference. Walter de Gruyter, Berlin 585-590 (1990)

15.    Lawson, D., Haas, R., Meyle, J. and Meyer, T.F., Molecular analysis of periodontal pathogens. Archives of Oral Biology, 35 101S-105S (1990).

14.    Meyer, T.F., Gibbs, C.P. and Haas, R., Variation and control of protein expression in Neisseria gonorrhoeae. Ann. Rev. Microbiol, 44: 451 (1990)

13.    Gibbs, C.P., Reimann, B.-Y., Schulz, E., Kaufmann, A., Haas, R. and Meyer, T.F, Reassortment of pilin genes in Neisseria gonorrhoeae occurs by two distinct mechanisms. Nature, 338:651-652 (1989)

12.    Meyer, T.F., Frosch, M., Gibbs, C.P., Haas, R., Halter, R., Pohlner, J. and van Putten, J.P.M., Virulence functions and antigen variation in pathogenic Neisseriae. Antonie van Leeuwenhoeck, 54:421-430 (1988)

11.    Gibbs, C., Haas, R. and Meyer, T. F., Structural and functional modulation of gonococcal surface proteins. Microbial Pathogenesis, 4:393-399 (1988)

10.    Meyer, T. F. and Haas, R., Phase and antigenic variation by DNA rearrangements in procaryotes. In: Transposition A.J. Kingsman, S.M. Kingsman, K.F. Chater (eds). Society for General Microbiology, 193-219 (1988)

9.    Haas, R. and Meyer, T.F., Molecular principles of pilus antigenic variation in Neisseria  gonorrhoeae. In: Gonococci and Meningococci, J.T. Poolman et al., (eds) 269-272 (1988)

8.    Meyer, T.F., Haas, R. and Stern, A., Antigenic variation of proteins on the surface of pathogenic Neisseriae. In: Molecular Basis of Viral and Microbial Pathogenesis. R. Rott, W. Goebel (eds). 38. Kolloquium Mosbach 114-122 (1987)
7.    Haas, R., Schwarz, H. and Meyer, T.F., Release of soluble pilin antigen coupled with gene conversion in Neisseria gonorrhoeae. Proc. Natl. Acad. Sci. USA, 84:9079-9083 (1987)

6.    Meyer, T.F., Fiedler, H., Frosch, M., Haas, R., Veit, S., Jähnig, F., Muralidharan, K. and Stern, A., Variable and conserved proteins on the surface of pathogenic Neisseriae. Bacterial Vaccines and Local Immunity. A. Tagliabue, R. Rappuoli, S.E. Piazzi (eds). Annali Sclavo 407-415 (1987)

5.    Haas, R., Nickel, P., Stern, A. and Meyer, T. F., Genomic organization of pilus and opacity genes in Neisseria gonorrhoeae. FEMS (Lark, Normark, Uhlin and Wolf-Watz, eds.), Protein-Carbohydrate Interactions in Biological Systems. Academic Press, London 81-87 (1986)

4.    Haas, R. and Meyer, T.F., The repertoire of silent pilus genes in Neisseria gonorrhoeae: evidence for gene conversion. Cell, 44:107-115 (1986)

3.    Meyer, T. F., Haas, R., Halter, R., Nickel, P., Pohlner, J., Stern A., Clarke, J., Delius, H. and So, M., Molecular analysis of virulence determinants of Neisseria gonorrhoeae. The Pathogenesis of Bacterial Infections, G. G. Jackson, H. Thomas, (eds) 221-234 (1985)

2.    Geider, K., Hohmeyer, C., Haas, R. and Meyer, T.F., A plasmid cloning system utilizing replication and packaging functions of the filamentous bacteriophage fd. Gene, 33:341-349 (1985)

1.    Meyer, T. F., Billyard, E., Haas, R., Störzbach, S. and So, M., Pilus genes in Neisseria gonorrhoeae: chromosomal organization and DNA sequence. Proc. Natl. Acad. Sci. USA 81, 6110-6114 (1984)