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Forschung > Medizinische Mikrobiologie und Krankenhaushygiene > AG PD Dr. W. Fischer > Publikationen > 

Publikationsliste W. Fischer

Steiner, T.M., Lettl, C., Schindele, F., Goebel, W., Haas, R., Fischer, W., and Eisenreich, W. (2021) Substrate usage determines carbon flux via the citrate cycle in Helicobacter pylori. Mol. Microbiol. (doi:10.1111/mmi.14775).

Lettl, C., Haas, R., and Fischer, W. (2021) Kinetics of CagA type IV secretion by Helicobacter pylori and the requirement for substrate unfolding. Mol. Microbiol. (doi: 10.1111/mmi.14772).

Lettl, C., Schindele, F., Testolin, G., Bär, A., Rehm, T., Brönstrup, M., Schobert, R., Bilitewski, U., Haas, R., and Fischer, W. (2020) Inhibition of type IV secretion activity and growth of Helicobacter pylori by cisplatin and other platinum complexes. Front. Cell. Infect. Microbiol. 10:602958 (doi: 10.3389/fcimb.2020.602958).

Palamides, P., Jolaiya, T., Idowu, A., Loell, E., Onyekwere, C., Ugiagbe, R., Agbo, I., Lesi, O., Ndububa, D., Akekanle, O., Carranza, M., Ally, R., Njom, H., Harrison, U., Clarke, A., Fischer, W., Smith, S., and Haas, R. (2020) Helicobacter pylori patient isolates from South Africa and Nigeria differ in virulence factor pathogenicity profile and associated gastric disease outcome. Sci. Rep. 10:11409 (doi: 10.1038/s41598-020-66128-0).

Hamway, Y., Taxauer, K., Moonens, K., Neumeyer, V., Fischer, W., Schmitt, V., Singer, B.B., Remaut, H., Gerhard, M., and Mejías-Luque, R. (2020) Cysteine residues in Helicobacter pylori adhesin HopQ are required for CEACAM-HopQ interaction and subsequent CagA translocation. Microorganisms 8:465 (doi:10.3390/microorganisms8040465).

Weiss, E., Spicher, C., Haas, R., and Fischer, W. (2019) Excision and transfer of an integrating and conjugative element in a bacterial species with high recombination efficiency. Sci. Rep. 9:8915 (doi: 10.1038/s41598-019-45429-z).

Fernández-Reyes, M., Tamayo, E., Rojas-Rengifo, D., Fischer, W., Carrasco-García, E., Alonso, M., Lizasoain, J., Bujanda, L., Cosme, A., and Montes, M. (2019) Helicobacter pylori pathogenicity and primary antimicrobial resistance in Northern Spain. Eur. J. Clin. Invest. 49:e13150 (doi: 10.1111/eci.13150).

Capitani, N., Codolo, G., Vallese, F., Minervini, G., Grassi, A., Cianchi, F., Troilo, A., Fischer, W., Zanotti, G., Baldari, C.T., de Bernard, M., and D’Elios, M.M. (2019) The lipoprotein HP1454 of Helicobacter pylori regulates T cell response by shaping T cell receptor signalling. Cell. Microbiol. 21:e13006 (doi: 10.1111/cmi.13006).

Zhao, Q., Busch, B., Jiménez-Soto, L.F., Ishikawa-Ankerhold, H., Massberg, S., Terradot, L., Fischer, W., and Haas, R. (2018) Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation. PLoS Pathog. 14:e1007359 (doi: 10.1371/journal.ppat.1007359).

Bonsor, D.A., Zhao, Q., Schmidinger, B., Weiss, E., Wang, J., Deredge, D., Beadenkopf, R., Dow, B., Fischer, W., Beckett, D., Wintrode, P.L., Haas, R., and Sundberg, E.J. (2018) The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA. EMBO J. 37:e98664 (DOI: 10.15252/embj.201798664).

Koelblen, T., Bergé, C., Cherrier, M.V., Brillet, K., Jiménez-Soto, L., Ballut, L., Takagi, J., Montserret, R., Rousselle, P., Fischer, W., Haas, R., Fronzes, R., and Terradot, L. (2017) Molecular dissection of protein-protein interactions between integrin α5β1 and the Helicobacter pylori Cag type IV secretion system. FEBS J. 284:4143-4157.

Messerer, M., Fischer, W., and Schubert, S. (2017) Investigation of horizontal gene transfer of pathogenicity islands in Escherichia coli using next-generation sequencing. PLoS One 12:e0179880.

Harrison, U., Fowora, M.A., Seriki, A.T., Loell, E., Mueller, S., Ugo-Ijeh, M., Onyekwere, C.A., Lesi, O.A., Otegbayo, J.A., Akere, A., Ndububa, D.A., Adekanle, O., Anomneze, E., Abdulkareem, F.B., Adeleye, I.A., Crispin, A., Rieder, G., Fischer, W., Smith, S.I., and Haas, R. (2017) Helicobacter pylori strains from a Nigerian cohort show divergent antibiotic resistance rates and a uniform pathogenicity profile. PLoS One 12:e0176454.

Santos, J.C., Brianti, M.T., Almeida, V.R., Ortega, M.M., Fischer, W., Haas, R., Matheu, A., and Ribeiro, M.L. (2017) Helicobacter pylori infection modulates the expression of miRNAs associated with DNA mismatch repair pathway. Mol. Carcinog. 56:1372-1379.

Bönig, T., Olbermann, P., Bats, S.H., Fischer, W., and Josenhans, C. (2016) Systematic site-directed mutagenesis of the Helicobacter pylori CagL protein of the Cag type IV secretion system identifies novel functional domains. Sci. Rep. 6:38101.

Königer, V., Holsten, L., Harrison, U., Busch, B., Loell, E., Zhao, Q., Bonsor, D.A., Roth, A., Kengmo-Tchoupa, A., Smith, S.I., Mueller, S., Sundberg, E.J., Zimmermann, W., Fischer, W., Hauck, C.R., and Haas, R. (2016) Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. Nat. Microbiol. 2:16188.

Zhong, Y., Anderl, F., Kruse, T., Schindele, F., Jagusztyn-Krynicka, E.K., Fischer, W., Gerhard, M., and Mejías-Luque, R. (2016) Helicobacter pylori HP0231 influences bacterial virulence and is essential for gastric colonization. PLoS One 11:e0154643.

Schindele, F., Weiss, E., Haas, R., and Fischer, W. (2016) Quantitative analysis of CagA type IV secretion by Helicobacter pylori reveals substrate recognition and translocation requirements. Mol. Microbiol. 100:188-203.

Vallese, F., Percudani, R., Fischer, W., and Zanotti, G. (2015) The crystal structure of Helicobacter pylori HP1029 highlights the functional diversity of the sialic acid-related DUF386 family. FEBS J. 282:3311-3322.

Bonsor, D.A., Pham, K.T., Beadenkopf, R., Diederichs, K., Haas, R., Beckett, D., Fischer, W., and Sundberg, E.J. (2015) Integrin engagement by the helical RGD motif of the Helicobacter pylori CagL protein is regulated by pH-induced displacement of a neighboring helix. J. Biol. Chem. 290:12929-12940.

Busch, B., Weimer, R., Woischke, C., Fischer, W., and Haas, R. (2015) Helicobacter pylori interferes with leukocyte migration via the outer membrane protein HopQ and via CagA translocation. Int. J. Med. Microbiol. 305:355-364.

Fischer, W., Breithaupt, U., Kern, B., Smith, S.I., Spicher, C., and Haas, R. (2014) A comprehensive analysis of Helicobacter pylori plasticity zones reveals that they are integrating conjugative elements with intermediate integration specificity. BMC Genomics 15:310.

Bonsor, D.A., Weiss, E., Iosub-Amir, A., Reingewertz, T.H., Chen, T.W., Haas, R., Friedler, A., Fischer, W., and Sundberg, E.J. (2013) Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF. J. Biol. Chem. 288:32897-32909.

Fischer, W., and Busch, B. (2013) The Helicobacter pylori CagA protein: A multifunctional bacterial toxin delivered by type IV secretion. In: Bacterial Toxins: Genetics, Cellular Biology and Practical Applications; T. Proft, Ed., Caister Academic Press, Norfolk, UK; pp. 13-45.

Rohrer, S., Holsten, L., Weiss, E., Benghezal, M., Fischer, W., and Haas, R. (2012) Multiple pathways of plasmid DNA transfer in Helicobacter pylori. PLoS One 7:e45623.

Pham, K.T., Weiss, E., Jiménez Soto, L.F., Breithaupt, U., Haas, R., and Fischer, W. (2012) CagI is an essential component of the Helicobacter pylori Cag type IV secretion system and forms a complex with CagL. PLoS One 7:e35341.

Fischer, W. (2011) Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus. FEBS J. 278:1203-1212. 

Jurik, A., Haußer, E., Kutter, S., Pattis, I., Praßl, S., Weiss, E., and Fischer, W. (2010) The coupling protein Cagbeta and its interaction partner CagZ are required for type IV secretion of the Helicobacter pylori CagA protein. Infect. Immun. 78:5244-5251.

Fischer, W., Windhager, L., Rohrer, S., Zeiller, M., Karnholz, A., Hoffmann, R., Zimmer, R., and Haas, R. (2010) Strain-specific genes of Helicobacter pylori: Genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res. 38:6089-6101.

Ding, S.-Z., Fischer, W., Kaparakis-Liaskos, M., Liechti, G., Merrell, D.S., Grant, P.A., Ferrero, R.L., Crowe, S.E., Haas, R., Hatakeyama, M., and Goldberg, J.B. (2010) Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. PLoS One 5:e9875.

Jiménez-Soto, L.F., Kutter, S., Sewald, X., Ertl, C., Weiss, E., Kapp, U., Rohde, M., Pirch, T., Jung, K., Retta, S.F., Terradot, L., Fischer, W., and Haas, R. (2009) Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. PLoS Pathog. 5:e1000684.

Kutter, S., Buhrdorf, R., Haas, J., Schneider-Brachert, W., Haas, R., and Fischer, W. (2008) Protein subassemblies of the Helicobacter pylori Cag type IV secretion system revealed by localization and interaction studies. J. Bacteriol. 190:2161-2171.

Pattis, I., Weiss, E., Laugks, R., Haas, R., and Fischer, W. (2007) The Helicobacter pylori CagF protein is a type IV secretion chaperone-like molecule that binds close to the C-terminal secretion signal of the CagA effector protein. Microbiology 153:2896-2909.

Hohlfeld, S., Pattis, I., Püls, J., Plano, G.V., Haas, R., and Fischer, W. (2006) A C-terminal secretion signal is necessary, but not sufficient for type IV secretion of the Helicobacter pylori CagA protein. Mol. Microbiol. 59:1624-1637.

Fischer, W., and Haas, R. (2004) The RecA protein of Helicobacter pylori requires a posttranslational modification for full activity. J. Bacteriol. 186:777-784.

Gebert, B., Fischer, W., Weiss, E., Hoffmann, R., and Haas, R. (2003) Helicobacter pylori vacuolating cytotoxin inhibits T-lymphocyte activation. Science 301:1099-1102.

Rohde, M., Püls, J., Buhrdorf, R., Fischer, W., and Haas, R. (2003) A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system. Mol. Microbiol. 49:219-234.

Buhrdorf, R., Förster, C., Haas, R., and Fischer, W. (2003) Topological analysis of a putative virB8 homologue essential for the cag type IV secretion system in Helicobacter pylori. Int. J. Med. Microbiol. 293:213-217. 

Kavermann, H., Burns, B.P., Angermüller, K., Odenbreit, S., Fischer, W., Melchers, K., and Haas, R. (2003) Identification and characterization of Helicobacter pylori genes essential for gastric colonization. J. Exp. Med. 197:813-822.

Fischer, W., Püls, J., Buhrdorf, R., Gebert, B., Odenbreit, S., and Haas, R. (2001) Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol. Microbiol. 42:1337-1348.

Fischer, W., Buhrdorf, R., Gerland, E., and Haas, R. (2001) Outer membrane targeting of passenger proteins by the vacuolating cytotoxin autotransporter of Helicobacter pylori. Infect. Immun. 69:6769-6775.

Odenbreit, S., Püls, J., Sedlmaier, B., Gerland, E., Fischer, W., and Haas, R. (2000) Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287:1497-1500.