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Forschung > Medizinische Mikrobiologie und Krankenhaushygiene > AG Prof. B. Stecher > Publikationen > 

Peer-reviewed publications 2002 - now
* equal contribution
# corresponding author

2018

Spriewald S., Stadler E., Obeng N., Hense B., Wagner J. and Stecher B. Evolutionary stabilization of cooperative toxin production through a bacterium-plasmid-phage interplay. submitted

van Vliet S, Dal Co A, Winkler AR, Spriewald S, Stecher B, Ackermann M. Spatially Correlated Gene Expression in Bacterial Groups: The Role of Lineage History, Spatial Gradients, and Cell-Cell Interactions. Cell Syst. 2018 Apr 25;6(4):496-507.e6. doi: 10.1016/j.cels.2018.03.009. Epub 2018 Apr 11.

Stecher B, Jung K. LACTATEing Salmonella: A Host-Derived Fermentation Product Fuels Pathogen Growth. Cell Host Microbe. 2018 Jan 10;23(1):3-4

2017

Garzetti D, Brugiroux S, Bunk B, Pukall R, McCoy KD, Macpherson AJ, Stecher B. High-Quality Whole-Genome Sequences of the Oligo-Mouse-Microbiota Bacterial Community. Genome Announc. 2017 Oct 19;5(42). pii: e00758-17. doi: 10.1128/genomeA.00758-17.PMID:29051233.

Münch PC, Stecher B, McHardy AC. EDEN: Evolutionary Dynamics within Environments. Bioinformatics. 2017 Jun 16. doi: 10.1093/bioinformatics/btx394.

Clavel T, Lagkouvardos I, Stecher B. From complex gut communities to minimal microbiomes via cultivation. Curr Opin Microbiol. 2017 Jun 15;38:148-155. doi: 10.1016/j.mib.2017.05.013.

Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T. CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. Nat Commun. 2017 Mar 9;8:14715. doi: 10.1038/ncomms14715. PMID: 28276457

Sadler R, Singh V, Benakis C, Garzetti D, Brea D, Stecher B, Anrather J, Liesz A. Microbiota differences between commercial breeders impacts the post-stroke immune response. Brain Behav Immun. 2017 Mar 24. pii: S0889-1591(17)30101-0. doi: 10.1016/j.bbi.2017.03.011. [Epub ahead of print] PMID: 28347867

Loy A, Pfann C, Steinberger M, Hanson B, Herp S, Brugiroux S, Gomes Neto JC, Boekschoten MV, Schwab C, Urich T, Ramer-Tait AE, Rattei T, Stecher B, Berry D. Lifestyle and Horizontal Gene Transfer-Mediated Evolution of Mucispirillum schaedleri, a Core Member of the Murine Gut Microbiota. mSystems. 2017 Jan 31;2(1). pii: e00171-16. doi: 10.1128/mSystems.00171-16. eCollection 2017 Jan-Feb.

Spriewald S., Stadler E., Obeng N., Hense B., Wagner J. and Stecher B. Evolutionary stabilization of cooperative toxin production through a bacterium-plasmid-phage interplay. submitted

Garzetti D, Brugiroux S, Bunk B, Pukall R, McCoy KD, Macpherson AJ, Stecher B. High-Quality Whole-Genome Sequences of the Oligo-Mouse-Microbiota Bacterial Community. Genome Announc. 2017 Oct 19;5(42). pii: e00758-17. doi: 10.1128/genomeA.00758-17.PMID:29051233.

Münch PC, Stecher B, McHardy AC. EDEN: Evolutionary Dynamics within Environments. Bioinformatics. 2017 Jun 16. doi: 10.1093/bioinformatics/btx394.

Clavel T, Lagkouvardos I, Stecher B. From complex gut communities to minimal microbiomes via cultivation. Curr Opin Microbiol. 2017 Jun 15;38:148-155. doi: 10.1016/j.mib.2017.05.013.

Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T. CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. Nat Commun. 2017 Mar 9;8:14715. doi: 10.1038/ncomms14715. PMID: 28276457

Sadler R, Singh V, Benakis C, Garzetti D, Brea D, Stecher B, Anrather J, Liesz A. Microbiota differences between commercial breeders impacts the post-stroke immune response. Brain Behav Immun. 2017 Mar 24. pii: S0889-1591(17)30101-0. doi: 10.1016/j.bbi.2017.03.011. [Epub ahead of print] PMID: 28347867

Loy A, Pfann C, Steinberger M, Hanson B, Herp S, Brugiroux S, Gomes Neto JC, Boekschoten MV, Schwab C, Urich T, Ramer-Tait AE, Rattei T, Stecher B, Berry D. Lifestyle and Horizontal Gene Transfer-Mediated Evolution of Mucispirillum schaedleri, a Core Member of the Murine Gut Microbiota. mSystems. 2017 Jan 31;2(1). pii: e00171-16. doi: 10.1128/mSystems.00171-16. eCollection 2017 Jan-Feb.

2016

Studer N, Desharnais L, Beutler M, Brugiroux S, Terrazos MA, Menin L, Schürch CM, McCoy KD, Kuehne SA, Minton NP, Stecher B, Bernier-Latmani R, Hapfelmeier S. Functional Intestinal Bile Acid 7α-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model. Front Cell Infect Microbiol. 2016 Dec 20;6:191. doi: 10.3389/fcimb.2016.00191. eCollection 2016. PMID: 28066726

Brugiroux S., Beutler M., Pfann C., Garzetti D., Ruscheweyh H.J., Ring D., Diehl M., Herp S., Lötscher Y., Hussain S., Bunk B., Pukall R., Huson D.H., Münch P.C., McHardy A.C., McCoy K.D., Macpherson A.J., Loy A., Clavel T., Berry D., Stecher B. Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium. Nat Microbiol. 2016 Nov 21;2:16215. doi: 10.1038/nmicrobiol.2016.215. PMID: 27869789.

Lagkouvardos, I., R., Pukall, Abt, B., Foesel, B.U., Meier-Kolthoff, J.P., Kumar, N., Bresciani, A., Martínez, I., Just, S., Ziegler, C., Brugiroux, S., Wenning, M., Bui, T.P.N., Wang, J., Hugenholtz, F., Plugge, C.M., Peterson, D., Hornef, M.W., Baines, J.F., Smidt, H., Walter, J., Kristiansen, K., Nielsen, H.B., Haller, D., Overmann, J., Stecher, B. and Clavel, T. The mouse intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the mouse gut microbiota. 2016 Nature Microbiol, doi 10.1038/nmicrobiol.2016.13

Uchimura Y., Wyss M., Brugiroux S., Limenitakis J.P., Stecher B., McCoy K.D., Macpherson A.J. Complete Genome Sequences of 12 Species of Stable Defined Moderately Diverse Mouse Microbiota 2.Genome Announc. 2016 Sep 15;4(5). pii: e00951-16. doi: 10.1128/genomeA.00951-16. PMID:  27634994.

Singh V, Roth S, Llovera G, Sadler R, Garzetti D, Stecher B, Dichgans M, Liesz A. Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke. J Neurosci. 2016 Jul 13;36(28):7428-40. doi: 10.1523

Andersen K, Kesper MS, Marschner JA, Konrad L, Ryu M, Kumar Vr S, Kulkarni OP, Mulay SR, Romoli S, Demleitner J, Schiller P, Dietrich A, Müller S, Gross O, Ruscheweyh HJ, Huson DH, Stecher B, Anders HJ. Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation. J Am Soc Nephrol. 2016 May 5.

Clavel T, Lagkouvardos I, Blaut M, Stecher B. The mouse gut microbiome revisited: From complex diversity to model ecosystems. Int J Med Microbiol. 2016 Mar 5. pii: S1438-4221(16)30017-0. doi: 10.1016/j.ijmm.2016.03.002.            PMID: 26995267

2015

Reporters for single-cell analysis of colicin Ib expression in Salmonella enterica serovar Typhimurium. Spriewald, S., Glaser, J., Beutler, M., Koeppel, M.B. and Stecher B. PLoS One. 2015 Dec10;10 (12):e0144647. doi: 10.1371/journal.pone.0144647. eCollection 2015

Nedialkova LP, Sidstedt M, Koeppel MB, Spriewald S, Ring D, Gerlach RG, Bossi L, Stecher B. Temperate phages promote colicin-dependent fitness of Salmonella enterica serovar Typhimurium. Environ Microbiol. 2015 Oct 6. doi: 

Li H, Limenitakis JP, Fuhrer T, Geuking MB, Lawson MA, Wyss M, Brugiroux S, Keller I, Macpherson JA, Rupp S, Stolp B, Stein JV, Stecher B, Sauer U, McCoy KD, Macpherson AJ. The outer mucus layer hosts a distinct intestinal microbial niche. Nat Commun. 2015 Sep 22;6:8292. doi: 10.1038/ncomms9292

Stecher B. The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection. Microbiol Spectr. 2015 Jun;3(3). doi: 10.1128/microbiolspec.MBP-0008-2014. PMID: 26185088

Erny D, Hrabì de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, Schwierzeck V, Utermöhlen O, Chun E, Garrett WS, McCoy KD, Diefenbach A7, Staeheli P, Stecher B, Amit I, Prinz M. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015 Jun 1. doi: 10.1038/nn.4030.

Göttig S, Gruber TM, Stecher B, Wichelhaus TA, Kempf VA. In Vivo Horizontal Gene Transfer of the Carbapenemase OXA-48 During a Nosocomial Outbreak. Clin Infect Dis. 2015 Mar 10. pii: civ191.PMID: 25759432

2014

Maier L, Diard M, Sellin ME, Chouffane ES, Trautwein-Weidner K, Periaswamy B, Slack E, Dolowschiak T, Stecher B, Loverdo C, Regoes RR, Hardt WD. Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis. PLoS Pathogens. 2014 Dec 18;10(12):e1004557. doi: 10.1371/journal.ppat.1004557. eCollection 2014 Dec. PMID: 25522364

Maier L, Barthel M, Stecher B, Maier RJ, Gunn JS, Hardt WD. Salmonella Typhimurium Strain ATCC14028 Requires H2-Hydrogenases for Growth in the Gut, but Not at Systemic Sites. PLoS One. 2014 Oct 10;9(10):e110187. doi: 10.1371/journal.pone.0110187. eCollection 2014.

Bergström JH, Berg KA, Rodríguez-Piñeiro AM, Stecher B, Johansson ME, Hansson GC. AGR2, an Endoplasmic Reticulum Protein, Is Secreted into the Gastrointestinal Mucus. PLoS One. 2014 Aug 11;9(8):e104186. doi: 10.1371/journal.pone.0104186. eCollection 2014.

Nedialkova L*, Denzler R.*, Koeppel M.B., Diehl M., Ring D., Gerlach R.G. and Stecher B#. Inflammation fuels colicin Ib-dependent competition of Salmonella serovar Typhimurium and E. coli in Enterobacterial blooms. PloS Pathogens. 2014 Jan;10(1):e1003844. Epub 2014 Jan 2.


2013

Maier L., Cordova C.D., Vyas R.,  Lindsay H., Schmidt T.S.B., Brugiroux S., Periaswamy B., Mering C.,  Robinson M.D., Stecher B. and Wolf-Dietrich Hardt. Microbiota-derived H2 fuels SalmonellaTyphimurium invasion of the gut ecosystem. Cell, Host and Microbe. 2013 Dec 11;14(6):641-51. doi: 10.1016/j.chom.2013.11.002.

Gronbach K, Flade I, Holst O, Lindner B, Ruscheweyh HJ, Wittmann A, Menz S, Schwiertz A, Adam P, Stecher B, Josenhans C, Suerbaum S, Gruber AD, Kulik A, Huson D, Autenrieth IB, Frick JS. Endotoxicity of Lipopolysaccharide as a Determinant of T-cell Mediated Colitis Induction in Mice.  Gastroenterology. 2013 Nov 21. doi:pii: S0016-5085(13)01711-3. 10

Stecher B. Finding a sugary foothold: how antibiotics pave the way for enteric pathogens. Cell Host Microbe. 2013 Sep 11;14(3):225-7.

Stecher B, Berry D, Loy A. Colonization resistance and microbial ecophysiology: using gnotobiotic mouse models and single-cell technology to explore the intestinal jungle. FEMS Microbiol Rev. 2013 Sep;37(5):793-829.

Heidegger S, Kirchner SK, Stephan N, Bohn B, Suhartha N, Hotz C, Anz D, Sandholzer N, Stecher B, Rüssmann H, Endres S, Bourquin C. TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice. J Immunol. 2013 May 15;190 (10):5313-20.

Berry D, Stecher B, Schintlmeister A, Reichert J, Brugiroux S, Wild B, Wanek W, Richter A, Rauch I, Decker T, Loy A, Wagner M. Host-compound foraging by intestinal microbiota revealed by single-cell stable isotope probing. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4720-5.

Stecher B, Maier L, Hardt WD. 'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution. Nat Rev Microbiol. 2013 Apr;11(4):277-84.

Anders HJ, Andersen K, Stecher B. The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease. Kidney Int. 2013 Jan 16. doi: 10.1038/ki.2012.440.

2012

Stecher B, Denzler R, Maier L, Bernet F, Sanders MJ, Pickard DJ, Barthel M, Westendorf AM, Krogfelt KA, Walker AW, Ackermann M, Dobrindt U, Thomson NR, Hardt WD.Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1269-74.

Kaiser, P., Diard M., Stecher B. and Hardt WD. The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen’s virulence factors and the host’s mucosal immune response. Immunological Reviews 2012 Jan;245(1):56-83.

2011

Songhet P, Barthel M, Stecher B, Müller AJ, Kremer M, Hansson GC, Hardt WD. Stromal IFN-γR-signaling modulates goblet cell function during Salmonella Typhimurium infection. PLoS One. 2011;6(7):e22459. Epub 2011 Jul 28.

Stecher B, Hardt WD. Mechanisms controlling pathogen colonization of the gut. Curr Opin Microbiol. 2011 Feb;14(1):82-91. Epub 2010 Oct 28. Review.

Misselwitz B, Kreibich SK, Rout S, Stecher B, Periaswamy B, Hardt WD.
Salmonella enterica serovar Typhimurium binds to HeLa cells via Fim-mediated reversible adhesion and irreversible type three secretion system 1-mediated docking. Infection and Immunity. 2011 Jan;79(1):330-41. Epub 2010 Oct 25.

2010

Endt K.*, Stecher B.*, Chaffron S., Slack E., Tchitchek N., Benecke A., Van Maele L., Sirard JC., Mueller A.J., Heikenwalder M., Macpherson A.J., Strugnell R., von Mering C. and Hardt WD# The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal diarrhea (2010) PLoS Pathogens, * equal contribution

Stecher B. # *,Chaffron S.*, Kaeppeli R.*, Hapfelmeier S., Freedrich S., Weber T.C., Kirundi J., Suar M., McCoy K., von Mering C. , Macpherson A.J. and Hardt WD. Like will to like: Abundances of closely related species as predictive values for the susceptibility to intestinal colonization by pathogenic and commensal bacteria (2010) PLoS Pathogens. #Corr. Author

2009

Schwan C., Stecher B., Tzivelekidis T., van Ham M., Rohde M., Hardt WD., Wehland J., Aktories K. Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathogens 2009 Oct;5(10):e1000626. Epub 2009 Oct 16.
 
Slack, E., Hapfelmeier, S., Stecher, B., Velykoredko, Y., Stoel, M., Lawson, M., Geuking, M.B., Beutler, B., Tedder, T.F., Hardt, W.D., Bercik, P., Verdu, E.F., McCoy K.M. and  Macpherson, A.J. A flexible continuum between adaptive and innate immunity in maintaining host-microbiota mutualism. Science. 2009 Jul 31;325(5940):617-20.
 
Ilg, K., Endt, K., Misselwitz, B., Stecher, B. , Aebi, M and Hardt, W.D. An O-antigen negative Salmonella enterica serovar Typhimurium is attenuated in intestinal colonisation but elicits colitis in streptomycin-treated mice. Infection and Immunity, 2009,June 2009, p. 2568-75, Vol. 77, No. 6.

2008

Sigurdson, C.J., Heikenwalder M., Manco, G., Barthel M., Schwarz, P., Stecher,B.,  Krautler, N.J., Hardt W.D., Seifert, B. MacPherson,A.J., Corthesy, I. and Aguzzi A. Bacterial Colitis Increases Susceptibility to Oral Prion Disease. The Journal of Infectious Diseases. 2008 Dec. 12.

Freed N.E., Silander O.K., Stecher B., Böhm, A., Hardt W.D. and Ackermann, M. A simple screen to identify promoters conferring high levels of phenotypic noise. PLoS Genetics. 2008 Dec; 4(12) e1000307
 
Ackermann M., Stecher B., Freed N.E., Songhet P., Hardt WD. and Michael Doebeli. Self-destructive cooperation mediated by phenotypic noise. Nature 454, 987-990 (21 August 2008)

Stecher B., Haberli L., Kremer M. and Hardt WD.  Chemotaxis allows S. Typhimurium to benefit from the mucosal defense. Cell Microbiol. 2008 Jan 30.
 
Stecher B. and Hardt WD.  Salmonella Typhimurium and the commensal flora. Review Trends in Microbiolgy, 2008 Mar;16(3):107-14.
 
Hapfelmeier S., Müller A.J., Stecher B., Patrick Kaiser, Barthel M., Endt K,  Eberhard M., Robbiani R., Jacobi C.A., Heikenwalder M., Kirschning C., Jung S.,  Stallmach T., Kremer M., and Wolf-Dietrich Hardt. Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in invG S. Typhimurium colitis. J Exp Med. 2008 Feb 18;205(2):437-50.
 
2007

Stecher B., Robbiani R.*, Walker A.W.*, Westendorf A.M., Barthel M., Kremer M., Chaffron S., Macpherson A.J., Buer J., Parkhill J., Dougan G., von Mering C.  and Hardt WD. Salmonella Typhimurium exploits inflammation to compete against the commensal flora (2007) PLoS Biology Aug 28;5(10).
 
Lang K.S., Navarini A.A., Recher M., Lang P.A., Heikenwalder M., Stecher B., Bergthaler A., Odermatt B., Akira S., Honda K., Hengartner H., Zinkernagel R. M. MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus. Eur. J. Immunol. 2007, Volume 37, Issue 9, Pages 2434-2440
 
Gerlach R.G., Jäckel D., Stecher B., Wagner D., Lupas A., Hardt W.D., Hensel M.   Salmonella Pathogenicity Island 4 encodes a giant non-fimbrial adhesin and the cognate type 1 secretion system. Cellular Microbiology 2007, 9 (7), 1834–1850

2006

Stecher B.*, Paesold G.*, Barthel M.,  Kremer M., Jantsch J., Stallmach T., Heikenwalder M. and Hardt WD. Chronic Salmonella enterica Serovar Typhimurium-Induced Colitis and Cholangitis in Streptomycin-Pretreated Nramp1+/+ Mice.  Infection and Immunity 2006 74: 5047-5057.
 
2005

Schlumberger MC, Muller AJ, Ehrbar K, Winnen B, Duss I, Stecher B., Hardt WD. Real-time imaging of type III secretion: Salmonella SipA injection into host cells. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12548-53.
 
Stecher B., Macpherson A., Hapfelmeier S., Kremer M.,  Stallmach T., Hardt WD. Comparison of Salmonella serovar Typhimurium colitis in streptomycin-pretreated and germfree mice. Infection and Immunity, 2005,June 2005, p. 3228-3241, Vol. 73, No. 6.
 
Hapfelmeier S., Stecher B., Barthel M., Kremer M., Muller A., Heikenwalder M., Stallmach T., Hensel M., Pfeffer K., Akira S., Hardt WD.  The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella serovar Typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms. The Journal of Immunology, 2005, 174: 1675-1685.
 
2004

Stecher B., Hapfelmeier S., Muller C., Stallmach T.,  Kremer M., Hardt WD. Flagella and Chemotaxis Are Required for Efficient Induction of Salmonella enterica Serovar Typhimurium Colitis in streptomycin-Pretreated Mice. Infection and Immunity, July 2004, p. 4138-4150, Vol. 72, No. 7
 
Ehrbar K., Hapfelmeier S., Stecher B., Hardt WD. InvB Is Required for Type III-Dependent Secretion of SopA in Salmonella enterica Serovar Typhimurium. Journal of Bacteriology, February 2004, p. 1215-1219, Vol. 186, No. 4
 
Hapfelmeier S., Ehrbar K., Stecher B., Barthel M., Kremer M., Hardt WD. Role of the Salmonella Pathogenicity Island 1 Effector Proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica Subspecies 1 Serovar Typhimurium Colitis in Streptomycin-Pretreated Mice. Infection and Immunity, February 2004, p. 795-809, Vol. 72, No. 270, No. 3

2002

Stecher B.*, Hansen-Wester I*., Hensel M. Type III Secretion of Salmonella enterica Serovar Typhimurium Translocated Effectors and SseFG. Infection and Immunity, March 2002, p. 1403-1409, Vol. 70, No. 3
 
Stecher B.*, Hansen-Wester I*, Hensel M. Analyses of the Evolutionary Distribution of Salmonella Translocated Effectors. Infection and Immunity, March 2002, p. 1619-1622, Vol.