für Hygiene und medizinische Mikrobiologie
der Ludwig-Maximilians-Universität München
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80336 München

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Key references: 

Genetic variation in H. pylori

Estibariz, I., F. Ailloud, S. Woltemate, B. Bunk, C. Spröer, J. Overmann, T. Aebischer, T. F. Meyer, C. Josenhans* und S. Suerbaum*. 2020. Early in vivo genome and methylome adaptation of cag-negative Helicobacter pylori during experimental human infection. mBio (im Druck)

Ailloud, F., X. Didelot, S. Woltemate, G. Pfaffinger, J. Overmann, R. C. Bader, C. Schulz, P. Malfertheiner, S. Suerbaum. 2019. Within-host evolution of Helicobacter pylori: niche-specific adaptation, migrations between gastric locations, and selective sweeps. Nat. Commun. 10:2273.

Estibariz, I., A. Overmann, F. Ailloud, J. Krebes, C. Josenhans, S. Suerbaum. 2019. The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori. Nucleic Acids Res. doi: 10.1093/nar/gky1307.

Nell, S., I. Estibariz, J. Krebes, B. Bunk, D. Y. Graham, J. Overmann, Y. Song, C. Spröer, I. Yang, T. Wex, J. Korlach, P. Malfertheiner, S. Suerbaum. 2018. Genome and methylome variation in Helicobacter pylori with a cag pathogenicity island during early stages of human infection. Gastroenterology 1654:612-623.

Bubendorfer, S., J. Krebes, I. Yang, E. Hage, T. F. Schulz, C. Bahlawane, X. Didelot, S. Suerbaum. 2016. Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori. Nat. Commun. 7:11995.

Nell, S., L. Kennemann, S. Schwarz, C. Josenhans, S. Suerbaum. 2014. Dynamics of Lewis b binding and sequence variation of the babA adhesin gene during chronic Helicobacter pylori infection in humans. mBio 5:e02281.

Didelot, X., S. Nell, I. Yang, S. Woltemate, S. van der Merwe, S. Suerbaum. 2013. Genomic evolution and transmission of Helicobacter pylori in two South African families. Proc. Natl. Acad. Sci. U.S.A. 110:13880-13885.

Kennemann, L., X. Didelot, T. Aebischer, S. Kuhn, B. Drescher, M. Droege, R. Reinhardt, P. Correa, T. F. Meyer, C. Josenhans, D. Falush, S. Suerbaum. 2011. Helicobacter pylori genome evolution during human infection. Proc. Natl. Acad. Sci. U.S.A. 108:5033-5038. 

Suerbaum, S., C. Josenhans. 2007. Helicobacter pylori evolution and phenotypic diversification in a changing host. Nat. Rev. Microbiol. 5:441-452.

Falush, D., T. Wirth, B. Linz, J. K. Pritchard, M. Stephens, M. Kidd, M. J. Blaser, D. Y. Graham, S. Vacher, G. I. Perez-Perez, Y. Yamaoka, F. Mégraud, K. Otto, U. Reichard, E. Katzowitsch, X. Wang, M. Achtman, S. Suerbaum. 2003. Traces of human migrations in Helicobacter pylori populations. Science 299:1582-1585.


Solbach, P., P. Chhatwal, S. Woltemate, E. Tacconelli, M. Buhl, I. B. Autenrieth, M. J. G. T. Vehreschild, N. Jazmati, M. Gerhard, C. K. Stein-Thoeringer, J. Rupp, K. Ulm, A. Ott, F. Lasch, A. Koch, M. P. Manns, S. Suerbaum*, O. Bachmann*. 2020. Microbiota-associated risk factors for C. difficile acquisition in hospitalized patients: A prospective, multicentric study. Clin. Infect. Dis. June 26 (Epub ahead of print)

Solbach, P., P. Chhatwal, S. Woltemate, E. Tacconelli, M. Buhl, M. Gerhard, C. K. Thoeringer, M. J. G. T. Vehreschild, N. Jazmati, J. Rupp, M. P. Manns, O. Bachmann, S. Suerbaum. 2018. BaiCD gene cluster abundance is negatively correlated with Clostridium difficile infection. PLoS ONE 13:e0196977.

Yang, I., S. Woltemate, M. B. Piazuelo, L. E. Bravo, M. C. Yepez, J. Romero-Gallo, A. G. Delgado, K. T. Wilson, R. M. Peek, Jr., P. Correa, C. Josenhans, J. G. Fox, S. Suerbaum. 2016. Different gastric microbiota compositions in two populations with high and low gastric cancer risk in Colombia. Sci. Rep. 6:18594.

Hernández, P. P., T. Mahlakoiv, I. Yang, V. Schwierzeck, N. Nguyen, F. Guendel, K. Gronke, B. Ryffel, C. Hoelscher, L. Dumoutier, J.-C. Renauld, S. Suerbaum, P. Staeheli, A. Diefenbach. 2015. Interferon-λ and interleukin-22 cooperate for the induction of interferon-stimulated genes and control of rotavirus infection. Nat. Immunol. 16:698-707.

Yang, I., D. Eibach, F. Kops, B. Brenneke, S. Woltemate, J. Schulze, A. Bleich, A. D. Gruber, S. Muthupalani, J. G. Fox, C. Josenhans, S. Suerbaum. 2013. Intestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis. PLoS ONE 8:e70783.

Yang, I., S. Nell und S. Suerbaum. 2013. Surviving in hostile territory: The microbiota of the stomach. FEMS Rev. Microbiol. 37:736-761.

Nell, S., S. Suerbaum und C. Josenhans. 2010. The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models. Nat. Rev. Microbiol. 8:564-577.

General reviews and guidelines:

Malfertheiner, P., F. Mégraud, C. A. O'Morain, J. P. Gisbert, E. J. Kuipers, A. T. Axon, F. Bazzoli, A. Gasbarrini, J. Atherton, D. Y. Graham, R. Hunt, P. Moayyedi, T. Rokkas, M. Rugge, M. Selgrad, S. Suerbaum, K. Sugano, E. M. El-Omar; European Helicobacter and Microbiota Study Group and Consensus panel. 2017. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut 66:6-30.

Suerbaum, S., P. Michetti. 2002. Helicobacter pylori infection. N. Engl. J. Med. 347:1175-1186 (> 1300 citations)

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