The bacteriological research groups

are focussing on topics of bacterial pathomechanisms/molecular infection biology, establishing suitable in vivo and in vitro infection models, bacterial modulation of the innate immune response, development of live vaccine carrier strain and pathogenicity of Aspergillus fumigatus.

Main issues are:

1. bacterial pathogens of the gastrointestinal tract (Helicobacter pylori, Yersinia enterocolitica, Salmonella enterica),
2. pathogens of the respiratory tract (Pseudomonas aeruginosa and Aspergillus fumigatus)
3. bacterial pathogens of the urogenital tract (Escherichia coli, pathotype UPEC/ExPEC)
4. live vaccine carrier strains, injecting antigens of interest into antigen presenting cells by type 3 protein secretion system (T3SS, Yersinia enterocolitica, Salmonella enterica)
5. analysis of the molecular mechanism of protein secretion/translocation by type 3- and type 4 secretion system (T3SS, T4SS)
6. development of diagnostic tools for infectious diseases and molecular epidemiology 

The virological research groups

are working at two places:
• groups in the main building in Munich centre at the 'Sendlinger Tor'
• groups in Gene centre at the Campus Munich Großhadern.

Main issues are:

1. cloning and mutagenese of Herpes virus genomes
2. production aund characterisation of dominant-negative mutants of essential proteins of cytomegaly viruses
3. investigation of modulation, activiation and inhibition of cellular genes by cytomegaly viruses in vitro und in vivo
4. tropism of cytomegaly viruses
5. Etablierung neuartiger RNA Markierungs- und Isolierungstechniken für Hochdurchsatzanalysen (Microarrays und Hochdurchsatz RNA-Sequenzierung)
6. biology and function of viral miRNAs at Herpes virus
7. protein-protein interactionen between viral and cellular proteins
8. Nucleo-cytoplasmatic transport during the Herpes virus-infection
9. Membran-associated processes of the Herpes virus Auswanderung
10. systematic recombinant expression of the Varizella Zoster proteoms to develop protein biochips
11. Non-viral episomale vector systems
12. development of improved hybrid vectors for gene therapy
13. influence of RNA interference mechanisms on gene transfer vectors