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The bacteriological research groups

are focussing on topics of bacterial pathomechanisms/molecular infection biology, establishing suitable in vivo and in vitro infection models, bacterial modulation of the innate immune response, development of live vaccine carrier strain and pathogenicity of Aspergillus fumigatus.

Main issues

  1. bacterial pathogens of the gastrointestinal tract (Helicobacter pylori, Yersinia enterocolitica, Salmonella enterica),
  2. pathogens of the respiratory tract (Legionella pneumophila, Pseudomonas aeruginosa and Aspergillus fumigatus)
  3. bacterial pathogens of the urogenital tract (Escherichia coli, pathotype UPEC/ExPEC)
  4. live vaccine carrier strains, injecting antigens of interest into antigen presenting cells by type 3 protein secretion system (T3SS, Yersinia enterocolitica, Salmonella enterica)
  5. analysis of the molecular mechanism of protein secretion/translocation by type 3- and type 4 secretion system (T3SS, T4SS)
  6. development of diagnostic tools for infectious diseases and molecular epidemiology 



The virological research groups

are located at three different sites:

Main issues are:

  1. DNA viruses (herpes viruses, adeno viruses): cloning and mutagenesis of herpesvirus genomes, tropism, trafficking, nucleo-zytoplasmatic transport of capsids, activation and inhibition of cellular genes by viral proteins and miRNAs, systems biology of the infected cell, antiviral therapy through dominant negative mutants and small molecules, vaccine development.
  2. RNA viruses (paramyxo-, rhabdo-, coronaviruses). Reverse genetics, innate immunity, interferon escape, neurobiology, neurotracing vectors, systems biology.