Aktuelles

Institute


Professor Lutz Gürtler, virologist and HIV researcher, was honored with the Federal Cross of Merit 1st Class in a ceremony at the Gärtnerplatz Theater by the Minister of Science and Art, Markus Blume, on behalf of the Bavarian State Ministry for Science and Arts. Professor Gürtler’s research has made a significant contribution to the early detection of the HIV virus.

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Institute


The Faculty of Medicine invites applications for a

Professorship (W2) (6 years/tenure track)
of
Medical Microbiology and Hygiene

commencing as soon as possible.

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Privacy Policy


1. An overview of data protection

General information

The following information will provide you with an easy to navigate overview of what will happen with your personal data when you visit this website. The term “personal data” comprises all data that can be used to personally identify you. For detailed information about the subject matter of data protection, please consult our Data Protection Declaration, which we have included beneath this copy.

Data recording on this website

Who is the responsible party for the recording of data on this website (i.e., the “controller”)?

The data on this website is processed by the operator of the website, whose contact information is available under section “Information about the responsible party (referred to as the “controller” in the GDPR)” in this Privacy Policy.

How do we record your data?

We collect your data as a result of your sharing of your data with us. This may, for instance be information you enter into our contact form.

Other data shall be recorded by our IT systems automatically or after you consent to its recording during your website visit. This data comprises primarily technical information (e.g., web browser, operating system, or time the site was accessed). This information is recorded automatically when you access this website.

What are the purposes we use your data for?

A portion of the information is generated to guarantee the error free provision of the website. Other data may be used to analyze your user patterns.

What rights do you have as far as your information is concerned?

You have the right to receive information about the source, recipients, and purposes of your archived personal data at any time without having to pay a fee for such disclosures. You also have the right to demand that your data are rectified or eradicated. If you have consented to data processing, you have the option to revoke this consent at any time, which shall affect all future data processing. Moreover, you have the right to demand that the processing of your data be restricted under certain circumstances. Furthermore, you have the right to log a complaint with the competent supervising agency.

Please do not hesitate to contact us at any time if you have questions about this or any other data protection related issues.

2. Hosting

We are hosting the content of our website at the following provider:

External Hosting

This website is hosted externally. Personal data collected on this website are stored on the servers of the host. These may include, but are not limited to, IP addresses, contact requests, metadata and communications, contract information, contact information, names, web page access, and other data generated through a web site.

The external hosting serves the purpose of fulfilling the contract with our potential and existing customers (Art. 6(1)(b) GDPR) and in the interest of secure, fast, and efficient provision of our online services by a professional provider (Art. 6(1)(f) GDPR). If appropriate consent has been obtained, the processing is carried out exclusively on the basis of Art. 6 (1)(a) GDPR and § 25 (1) TTDSG, insofar the consent includes the storage of cookies or the access to information in the user’s end device (e.g., device fingerprinting) within the meaning of the TTDSG. This consent can be revoked at any time.

Our host(s) will only process your data to the extent necessary to fulfil its performance obligations and to follow our instructions with respect to such data.

We are using the following host(s):

HOSTING-KONTAKT
ANSCHRIFT

3. General information and mandatory information

Data protection

The operators of this website and its pages take the protection of your personal data very seriously. Hence, we handle your personal data as confidential information and in compliance with the statutory data protection regulations and this Data Protection Declaration.

Whenever you use this website, a variety of personal information will be collected. Personal data comprises data that can be used to personally identify you. This Data Protection Declaration explains which data we collect as well as the purposes we use this data for. It also explains how, and for which purpose the information is collected.

We herewith advise you that the transmission of data via the Internet (i.e., through e-mail communications) may be prone to security gaps. It is not possible to completely protect data against third-party access.

Information about the responsible party (referred to as the “controller” in the GDPR)

 

The controller is the natural person or legal entity that single-handedly or jointly with others makes decisions as to the purposes of and resources for the processing of personal data (e.g., names, e-mail addresses, etc.).

Storage duration

Unless a more specific storage period has been specified in this privacy policy, your personal data will remain with us until the purpose for which it was collected no longer applies. If you assert a justified request for deletion or revoke your consent to data processing, your data will be deleted, unless we have other legally permissible reasons for storing your personal data (e.g., tax or commercial law retention periods); in the latter case, the deletion will take place after these reasons cease to apply.

General information on the legal basis for the data processing on this website

If you have consented to data processing, we process your personal data on the basis of Art. 6(1)(a) GDPR or Art. 9 (2)(a) GDPR, if special categories of data are processed according to Art. 9 (1) DSGVO. In the case of explicit consent to the transfer of personal data to third countries, the data processing is also based on Art. 49 (1)(a) GDPR. If you have consented to the storage of cookies or to the access to information in your end device (e.g., via device fingerprinting), the data processing is additionally based on § 25 (1) TTDSG. The consent can be revoked at any time. If your data is required for the fulfillment of a contract or for the implementation of pre-contractual measures, we process your data on the basis of Art. 6(1)(b) GDPR. Furthermore, if your data is required for the fulfillment of a legal obligation, we process it on the basis of Art. 6(1)(c) GDPR. Furthermore, the data processing may be carried out on the basis of our legitimate interest according to Art. 6(1)(f) GDPR. Information on the relevant legal basis in each individual case is provided in the following paragraphs of this privacy policy.

Revocation of your consent to the processing of data

A wide range of data processing transactions are possible only subject to your express consent. You can also revoke at any time any consent you have already given us. This shall be without prejudice to the lawfulness of any data collection that occurred prior to your revocation.

Right to object to the collection of data in special cases; right to object to direct advertising (Art. 21 GDPR)

IN THE EVENT THAT DATA ARE PROCESSED ON THE BASIS OF ART. 6(1)(E) OR (F) GDPR, YOU HAVE THE RIGHT TO AT ANY TIME OBJECT TO THE PROCESSING OF YOUR PERSONAL DATA BASED ON GROUNDS ARISING FROM YOUR UNIQUE SITUATION. THIS ALSO APPLIES TO ANY PROFILING BASED ON THESE PROVISIONS. TO DETERMINE THE LEGAL BASIS, ON WHICH ANY PROCESSING OF DATA IS BASED, PLEASE CONSULT THIS DATA PROTECTION DECLARATION. IF YOU LOG AN OBJECTION, WE WILL NO LONGER PROCESS YOUR AFFECTED PERSONAL DATA, UNLESS WE ARE IN A POSITION TO PRESENT COMPELLING PROTECTION WORTHY GROUNDS FOR THE PROCESSING OF YOUR DATA, THAT OUTWEIGH YOUR INTERESTS, RIGHTS AND FREEDOMS OR IF THE PURPOSE OF THE PROCESSING IS THE CLAIMING, EXERCISING OR DEFENCE OF LEGAL ENTITLEMENTS (OBJECTION PURSUANT TO ART. 21(1) GDPR).

IF YOUR PERSONAL DATA IS BEING PROCESSED IN ORDER TO ENGAGE IN DIRECT ADVERTISING, YOU HAVE THE RIGHT TO OBJECT TO THE PROCESSING OF YOUR AFFECTED PERSONAL DATA FOR THE PURPOSES OF SUCH ADVERTISING AT ANY TIME. THIS ALSO APPLIES TO PROFILING TO THE EXTENT THAT IT IS AFFILIATED WITH SUCH DIRECT ADVERTISING. IF YOU OBJECT, YOUR PERSONAL DATA WILL SUBSEQUENTLY NO LONGER BE USED FOR DIRECT ADVERTISING PURPOSES (OBJECTION PURSUANT TO ART. 21(2) GDPR).

Right to log a complaint with the competent supervisory agency

In the event of violations of the GDPR, data subjects are entitled to log a complaint with a supervisory agency, in particular in the member state where they usually maintain their domicile, place of work or at the place where the alleged violation occurred. The right to log a complaint is in effect regardless of any other administrative or court proceedings available as legal recourses.

Right to data portability

You have the right to demand that we hand over any data we automatically process on the basis of your consent or in order to fulfil a contract be handed over to you or a third party in a commonly used, machine readable format. If you should demand the direct transfer of the data to another controller, this will be done only if it is technically feasible.

Information about, rectification and eradication of data

Within the scope of the applicable statutory provisions, you have the right to at any time demand information about your archived personal data, their source and recipients as well as the purpose of the processing of your data. You may also have a right to have your data rectified or eradicated. If you have questions about this subject matter or any other questions about personal data, please do not hesitate to contact us at any time.

Right to demand processing restrictions

You have the right to demand the imposition of restrictions as far as the processing of your personal data is concerned. To do so, you may contact us at any time. The right to demand restriction of processing applies in the following cases:

  • In the event that you should dispute the correctness of your data archived by us, we will usually need some time to verify this claim. During the time that this investigation is ongoing, you have the right to demand that we restrict the processing of your personal data.
  • If the processing of your personal data was/is conducted in an unlawful manner, you have the option to demand the restriction of the processing of your data in lieu of demanding the eradication of this data.
  • If we do not need your personal data any longer and you need it to exercise, defend or claim legal entitlements, you have the right to demand the restriction of the processing of your personal data instead of its eradication.
  • If you have raised an objection pursuant to Art. 21(1) GDPR, your rights and our rights will have to be weighed against each other. As long as it has not been determined whose interests prevail, you have the right to demand a restriction of the processing of your personal data.

If you have restricted the processing of your personal data, these data – with the exception of their archiving – may be processed only subject to your consent or to claim, exercise or defend legal entitlements or to protect the rights of other natural persons or legal entities or for important public interest reasons cited by the European Union or a member state of the EU.

SSL and/or TLS encryption

For security reasons and to protect the transmission of confidential content, such as purchase orders or inquiries you submit to us as the website operator, this website uses either an SSL or a TLS encryption program. You can recognize an encrypted connection by checking whether the address line of the browser switches from “http://” to “https://” and also by the appearance of the lock icon in the browser line.

If the SSL or TLS encryption is activated, data you transmit to us cannot be read by third parties.

Rejection of unsolicited e-mails

We herewith object to the use of contact information published in conjunction with the mandatory information to be provided in our Site Notice to send us promotional and information material that we have not expressly requested. The operators of this website and its pages reserve the express right to take legal action in the event of the unsolicited sending of promotional information, for instance via SPAM messages.

4. Recording of data on this website

Cookies

Our websites and pages use what the industry refers to as “cookies.” Cookies are small data packages that do not cause any damage to your device. They are either stored temporarily for the duration of a session (session cookies) or they are permanently archived on your device (permanent cookies). Session cookies are automatically deleted once you terminate your visit. Permanent cookies remain archived on your device until you actively delete them, or they are automatically eradicated by your web browser.

Cookies can be issued by us (first-party cookies) or by third-party companies (so-called third-party cookies). Third-party cookies enable the integration of certain services of third-party companies into websites (e.g., cookies for handling payment services).

Cookies have a variety of functions. Many cookies are technically essential since certain website functions would not work in the absence of these cookies (e.g., the shopping cart function or the display of videos). Other cookies may be used to analyze user behavior or for promotional purposes.

Cookies, which are required for the performance of electronic communication transactions, for the provision of certain functions you want to use (e.g., for the shopping cart function) or those that are necessary for the optimization (required cookies) of the website (e.g., cookies that provide measurable insights into the web audience), shall be stored on the basis of Art. 6(1)(f) GDPR, unless a different legal basis is cited. The operator of the website has a legitimate interest in the storage of required cookies to ensure the technically error-free and optimized provision of the operator’s services. If your consent to the storage of the cookies and similar recognition technologies has been requested, the processing occurs exclusively on the basis of the consent obtained (Art. 6(1)(a) GDPR and § 25 (1) TTDSG); this consent may be revoked at any time.

You have the option to set up your browser in such a manner that you will be notified any time cookies are placed and to permit the acceptance of cookies only in specific cases. You may also exclude the acceptance of cookies in certain cases or in general or activate the delete-function for the automatic eradication of cookies when the browser closes. If cookies are deactivated, the functions of this website may be limited.

Which cookies and services are used on this website can be found in this privacy policy.

Consent with Borlabs Cookie

Our website uses the Borlabs consent technology to obtain your consent to the storage of certain cookies in your browser or for the use of certain technologies and for their data privacy protection compliant documentation. The provider of this technology is Borlabs GmbH, Rübenkamp 32, 22305 Hamburg, Germany (hereinafter referred to as Borlabs).

Whenever you visit our website, a Borlabs cookie will be stored in your browser, which archives any declarations or revocations of consent you have entered. These data are not shared with the provider of the Borlabs technology.

The recorded data shall remain archived until you ask us to eradicate them, delete the Borlabs cookie on your own or the purpose of storing the data no longer exists. This shall be without prejudice to any retention obligations mandated by law. To review the details of Borlabs’ data processing policies, please visit https://de.borlabs.io/kb/welche-daten-speichert-borlabs-cookie/

We use the Borlabs cookie consent technology to obtain the declarations of consent mandated by law for the use of cookies. The legal basis for the use of such cookies is Art. 6(1)(c) GDPR.

Contact form

If you submit inquiries to us via our contact form, the information provided in the contact form as well as any contact information provided therein will be stored by us in order to handle your inquiry and in the event that we have further questions. We will not share this information without your consent.

The processing of these data is based on Art. 6(1)(b) GDPR, if your request is related to the execution of a contract or if it is necessary to carry out pre-contractual measures. In all other cases the processing is based on our legitimate interest in the effective processing of the requests addressed to us (Art. 6(1)(f) GDPR) or on your agreement (Art. 6(1)(a) GDPR) if this has been requested; the consent can be revoked at any time.

The information you have entered into the contact form shall remain with us until you ask us to eradicate the data, revoke your consent to the archiving of data or if the purpose for which the information is being archived no longer exists (e.g., after we have concluded our response to your inquiry). This shall be without prejudice to any mandatory legal provisions, in particular retention periods.

Request by e-mail, telephone, or fax

If you contact us by e-mail, telephone or fax, your request, including all resulting personal data (name, request) will be stored and processed by us for the purpose of processing your request. We do not pass these data on without your consent.

These data are processed on the basis of Art. 6(1)(b) GDPR if your inquiry is related to the fulfillment of a contract or is required for the performance of pre-contractual measures. In all other cases, the data are processed on the basis of our legitimate interest in the effective handling of inquiries submitted to us (Art. 6(1)(f) GDPR) or on the basis of your consent (Art. 6(1)(a) GDPR) if it has been obtained; the consent can be revoked at any time.

The data sent by you to us via contact requests remain with us until you request us to delete, revoke your consent to the storage or the purpose for the data storage lapses (e.g. after completion of your request). Mandatory statutory provisions – in particular statutory retention periods – remain unaffected.

5. Analysis tools and advertising

Matomo

This website uses the open-source web analysis service Matomo.

Through Matomo, we are able to collect and analyze data on the use of our website-by-website visitors. This enables us to find out, for instance, when which page views occurred and from which region they came. In addition, we collect various log files (e.g. IP address, referrer, browser, and operating system used) and can measure whether our website visitors perform certain actions (e.g. clicks, purchases, etc.).

The use of this analysis tool is based on Art. 6(1)(f) GDPR. The website operator has a legitimate interest in the analysis of user patterns, in order to optimize the operator’s web offerings and advertising. If appropriate consent has been obtained, the processing is carried out exclusively on the basis of Art. 6(1)(a) GDPR and § 25 (1) TTDSG, insofar the consent includes the storage of cookies or the access to information in the user’s end device (e.g., device fingerprinting) within the meaning of the TTDSG. This consent can be revoked at any time.

IP anonymization

For analysis with Matomo we use IP anonymization. Your IP address is shortened before the analysis, so that it is no longer clearly assignable to you.

Analysis without cookies

We have configured Matomo in such a way that Matomo will not store cookies in your browser.

Hosting

We host Matomo exclusively on our own servers so that all analysis data remains with us and is not passed on.

6. Plug-ins and Tools

iThemes Security

We have integrated iThemes Security into this website. The provider is iThemes Media LLC, 1720 South Kelly Avenue Edmond, OK 73013, USA (hereinafter referred to as “iThemes Security”).

iThemes Security protects our website against undesirable access or malicious cyber-attacks. For this purpose, iThemes Security records, among other things, your IP address, the time, and source of login attempts and log files (e.g., the utilized browser). iThemes Security is installed locally on our servers.

The use of iThemes Security is based on Art. 6(1)(f) GDPR. The website operator has a legitimate interest in protecting its website optimally against cyber-attacks. If appropriate consent has been obtained, the processing is carried out exclusively on the basis of Art. 6(1)(a) GDPR and § 25 (1) TTDSG, insofar the consent includes the storage of cookies or the access to information in the user’s end device (e.g., device fingerprinting) within the meaning of the TTDSG. This consent can be revoked at any time.

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Research


Internationally visible infection research is a central task of the Max von Pettenkofer Institute. At the Institute’s two chairs of Medical Microbiology and Hospital Hygiene (Director: Prof. Dr. S. Suerbaum) and of Virology (Director: Prof. Dr. O. T. Keppler), we work on a broad spectrum of topics and projects with approximately 12 research groups. Our research activities include basic research on infectious agents and their interaction with the human host, translational research, diagnostic issues and participation in clinical trials.

Our research activities are supported by third-party funding from various funding institutions, including the German Research Foundation, the Federal Ministry of Education and Research, as well as the Federal Ministry of Health, the German Centre for Infection Research and the Bavarian State Ministries of Science and the Arts and of Health.

 

 Check out our new interactive website MIVIM

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History of the Institute - from the Anniversary Publication of the 200th birthday of Max von Pettenkofer

Max von Pettenkofer (1818-1901) – forward thinker in public health and founder of the world’s first center of excellence in hygiene.

With his diverse and varied life’s work, Max von Pettenkofer is one of the most exciting minds in 19th century science. From a poor farmer’s son and short-lived dropout, he made it to the scientific elite and, as president of the Academy of Sciences, even to the highest-ranking representative of the research disciplines in the Kingdom of Bavaria. He achieved extraordinary things in many fields. However, Pettenkofer discovered his true mission with scientific hygiene, for which he conclusively built an entire edifice of thought. As a thought leader in health care, he created trends in public health. Pettenkofer turned his teaching and research institute into the world’s first center of excellence for hygiene, which attracted students from all over the world and became the international flagship of the University of Munich. Pettenkofer’s hygiene think tank became the hub of a global network.

 

Starting points: Chemistry and cholera

Although Max von Pettenkofer studied pharmacy and medicine in Munich from 1837, he never practiced medicine. He much preferred researching the processes in the human organism as a chemist even in his young life. With this choice, Pettenkofer demonstrated the right instinct for highly topical research and at the same time helped to make chemistry the key subject in contemporary medicine. The chemical branch of knowledge was trusted to finally shed light on the darkness that for centuries had hidden the inner life of the sick person from medical view and understanding. Already in the laboratory of Justus von Liebig in Giessen, where Pettenkofer trained, he displayed a high degree of independence in chemical thinking and discovered numerous detection methods for substances occurring in the human body and its juices. His appointment as professor of medicinal chemistry at the University of Munich in 1847 marked the first step on Pettenkofer’s career ladder, and in 1853 he was promoted to full professor of organic chemistry in the medical faculty. Throughout his life, Pettenkofer saw himself primarily as a medicinal chemist. This also applies to his work in the field of hygiene.

With his research on the origin and spread of cholera, Pettenkofer made a name for himself internationally as an epidemiologist in addition to his excellent reputation as a chemist. The epidemic, which originated in India, brought chaos and death to Europe in the 19th century. Even though Pettenkofer’s interpretation of cholera, the epidemic-relevant developmental step of which he placed in the soil, led him down a monstrously wrong path, the recommendations derived from it for warding off cholera proved to be extremely beneficial. The hydrological infrastructure recommended by Pettenkofer to purify the soil in cities – an efficient water supply with sufficient pressure in combination with a sufficient alluvial sewer system – were not only major technical projects, but also formed a new infrastructure for health. Max von Pettenkofer contributed significantly to people’s health happiness. In his cholera research, Max von Pettenkofer recognized, on the one hand, the elementary importance of prevention and, on the other, the fact that diseases and epidemics obviously have a lot to do with filth and unhygienic environmental and living conditions. This insight led him to take a closer look at the subject of hygiene. And as with the fight against cholera, he soon set new standards in this area as well.

 

Project Hygiene

Hygiene refers to the totality of all measures taken to protect and promote the health conditions of individuals and human society. When Pettenkofer began his efforts in this regard, the hygienic conditions were alarming. Especially in underprivileged residential areas, conditions were dire. Many people lived in one apartment, and sanitary facilities were rudimentary. Even if people were not yet afraid of bacteria – they had not yet been discovered – other pests were all the more numerous.

The fact that environmental factors and personal hygiene play a role in dealing with health risks had been thought of since ancient times. Pettenkofer drew on this ancient tradition of knowledge on the one hand and the contemporary sanitary reform ideas in France and England on the other, and placed himself at the forefront of this movement. As a genuine scientist, he was disturbed by the fact that – on closer examination – medical experts in the field of health care knew in principle little more than any lay person equipped with common sense. Pettenkofer drew a sharp line between himself and this rather intuitive “gut knowledge” and declared it his goal to capture hygiene with the language of modern science. He wanted to be able to say with certainty exactly what “fresh air” and “clean water” were in scientific precision and terminology, what constituted “good food” and what constituted “good clothing,” and when a home was truly “healthy.”

For Pettenkofer, deciphering the interactions between the human organism and its immediate environment formed the basic prerequisite for effective prevention of diseases and epidemics. Pettenkofer opened up the immediate space around the human organism, as it were, and gave people a new view of their world. This included topics such as soil, air and water quality, the influence of soil on the spread of diseases, the ventilation and heating of premises, the hygienic value of plants inside the home, personal hygiene, the function of clothing or cleanliness in the home and on the street.

Pettenkofer did not invent hygiene. But he ensured reliable knowledge production in the field of hygiene by consistently applying the experimental method. It was precisely for this achievement that Pettenkofer was awarded the golden Harben Medal in 1897 by the British Royal Institute for Public Health, at that time the world’s highest award in the field of hygiene. Pettenkofer endeavored to provide a secure scientific basis for measures that had previously been applied more intuitively or on an empirical basis. Thus, Max von Pettenkofer’s name is indeed associated with breakthroughs in modern hygiene and prevention as well as public health. In this sense, Pettenkofer is rightly considered the “father of modern hygienic science,” as the Reich Health Office once honorably dubbed him. To progress along his path, Pettenkofer combined medical expertise with the latest knowledge from physics, chemistry, technology, statistics and economics. All these different parameters together formed the basis of hygiene. With this “crossover thinking,” which is considered particularly progressive even from today’s perspective, he made hygiene the first interdisciplinary subject in medicine.

 

Hygiene as a subject and research field

Pettenkofer’s aim was to record the health-relevant relationships between the human organism and its environment without speculation and with scientific conciseness. He wanted to record all factors that contributed to a healthy life. With changing teams and collaborators, Pettenkofer set about researching these aspects and set standards worldwide.

The focus was on the three classical elements of air, water and earth. For Pettenkofer, keeping the air clean was an elementary task of health care and an urgent concern for residential hygiene. His studies on indoor climate also gave rise to the Pettenkofer number, which is still used today to assess indoor air quality. Pettenkofer’s measurements documented that the air in homes, schools, inns, and other locations was far from atmospheric air quality. In search of a simple measure for comparing the quality of indoor and outdoor air, Pettenkofer came up with carbonic acid, which was present in both indoor and outdoor air and could be easily measured using the method he developed. The carbon dioxide content served him as a measure of the volatile organic substances emitted by humans, which were actually responsible for a good or bad indoor climate. Pettenkofer determined that above a carbon dioxide concentration of one per mille, the air in an indoor space no longer met hygienic requirements. In connection with the quality of indoor air, ventilation and heating now became particularly important.

Since, in addition to air, water plays a central role in human life, Pettenkofer also turned his attention to water quality. Hygienically safe water remained a scarce commodity until the middle of the 19th century. Even though Pettenkofer underestimated the role of drinking water in the development of epidemics, he gave drinking water quality the highest priority and developed an exemplary quality control system for the precious water. Dirty water, like polluted air, poor food, unhealthy clothing, or individual excesses in life, could disrupt physiological processes in the human body, making individuals more susceptible to disease. With the testing program he developed, Pettenkofer made a major contribution to determining quality criteria for hygienically safe drinking water, which cities then used as a guide when setting up modern centralized water supplies. As early as the mid-1880s, microbiological tests were also part of the program to see whether water was contaminated with microorganisms.

For Pettenkofer, the development of a healthy environment also included the so-called assanitation of the soil. Since in Pettenkofer’s medical worldview the soil played a very special role in the spread of an epidemic such as the dreadful cholera, the assessment of the soil and its condition was a central point in addition to the above-mentioned cleaning of the soil. He developed a whole spectrum of factors that became relevant in urban planning and for the selection of building sites from an epidemiological point of view.

A healthy life included not only clean air and healthy living spaces, but also clean water and clean ground, proper clothing, personal hygiene and good food. Thus, Pettenkofer researched the physiological significance of our clothing and its interaction with the skin. He examined microscopically the substances used in clothing manufacture and analyzed the physical properties of textiles. At the top of his agenda was also personal hygiene. For Pettenkofer, bodily uncleanliness was the “most dangerous breeding ground for all diseases.” The new plentiful supply of running water improved bathing and showering facilities and facilitated regular washing with soap.

 

Hygiene as an academic discipline

The science of hygiene owes Pettenkofer not only a coherent body of thought, but also its academic anchoring in teaching. Pettenkofer ensured that thorough knowledge of hygiene and public health care became general medical knowledge. At his instigation, Bavaria was the first state to include hygiene in the compulsory curriculum in 1865 and established chairs for the subject, which were assigned to chemists entirely in accordance with Pettenkofer’s understanding. Pettenkofer himself received the newly established chair in Munich. Vienna and Leipzig followed in 1875 and 1878 as the next universities in the German-speaking world to establish chairs in hygiene. Amsterdam also established a professorship for hygiene as early as 1878. In 1882, all the states in the German Empire followed the path set by Bavaria and also made hygiene a compulsory subject.

After the subject of hygiene had been included in medical studies and even given a chair, a suitable teaching and research institution was still lacking. Initially, Pettenkofer had been given premises in the university building for a chemical laboratory. In 1855, he moved his “Laboratory for Physiological Chemistry” to the newly built Physiological Institute, where he remained until 1879. As the holder of a chair in hygiene, however, Pettenkofer converted his institution into a “Chemical Laboratory for Hygiene” as early as 1870. When Pettenkofer turned down an extremely tempting call to the University of Vienna in 1872, because it was associated with the promise of a new institute, the financial channels for a new institute building also opened in Bavaria. The ceremonial opening of the Hygiene Institute on April 19, 1879, impressively confirmed Max von Pettenkofer’s previous work. With two lecture halls and several laboratories as well as examination facilities, the new institute was excellently equipped for its tasks.

 

Think tank and competence center for hygiene

Pettenkofer subsequently developed the institute he had set up for systematic teaching and research in 1879 into a globally unique competence center for hygiene and environmental medicine. Pettenkofer’s think tank for hygiene became the ground station of his global hygiene mission. Soon the whole world was seeking advice and information from Pettenkofer on hygienic issues, and students made pilgrimages from far and wide to learn from Pettenkofer and from each other about “hygiene.” His teaching and research program met with great interest worldwide and allowed Munich to rise to become a global center of hygiene. Hygiene of the Pettenkofer brand became a Bavarian export to the whole world in the second half of the 19th century.

From Central, Southern, Eastern and Northern Europe, from England and Scotland, North and South America, from Russia and especially from faraway Japan, young doctors and researchers flocked to Max von Pettenkofer to learn hygiene from him. With his motivating personality, Pettenkofer captivated the young people. They took Pettenkofer’s knowledge back home with them and ensured a worldwide transfer of knowledge across national borders. A particular geographical focus in this respect was clearly Russia and Japan. In Moscow, Friedrich Huldreich Erismann (1842-1915), who came from Switzerland but was married to a Russian doctor and influenced by Pettenkofer, was appointed to the chair of hygiene at the University of Moscow in 1884, along with his own institute. As Erismann’s successor, Sergei Bubnov (1851-1909), another physician trained by Pettenkofer, took over the chair of hygiene in Moscow in 1896. Bubnow, who presided over the large International Hygiene Congress in Moscow in 1897, had worked with Pettenkofer in the early 1870s on sewerage issues and on housing, clothing and food hygiene. Among the young researchers who also made early pilgrimages to Pettenkofer from the Russian-speaking world were Aleksej Dobroslawin (1842-1889), Viktor Subbotin (1844-1898), Arkadij Jakobij (1837-1907) and Alexander Sudakow. Dobroslavin, who wrote a textbook on public health in 1882, subsequently received a chair of hygiene at the military academy in St. Petersburg, Subbotin became a full professor in Kiev, and Jakobij was responsible for teaching hygiene in Kharkov from the 1870s before moving to Kazan as a professor of hygiene in 1885. Sudakov taught hygiene in Tomsk from 1887, where he became a full professor in 1890.

 

In addition to the Russian Tsarist Empire, Japan sent a number of physicians to Pettenkofer. It was the time of the Meiji Reform, when Japan opened up to the West and adopted the best and most advanced from Europe. This included modern German medicine and, above all, hygiene. Numerous young doctors not only visited Pettenkofer, but also took courses with Robert Koch in Berlin. Among the well-known visiting physicians from Japan was the plague researcher Masanori Ogata (1854-1919), who returned to Tokyo in 1885 and was entrusted with the new teaching institution at the university along with the public health office. Pettenkofer’s ideas were spread in Japan mainly by the highest-ranking military physician Rintaro Mori (1862-1922), better known as Mori Ogai, or Jiro Tsuboi (1862-1903), who became the first dean of the medical school at Kyoto Imperial University in 1899; and finally Shimpei Gotoh (1857-1929), who, in addition to his merits in government service as a facilitator of modern hygiene, even made it to the position of Minister of the Interior and Foreign Affairs of the Japanese Empire and Mayor of Tokyo.

In other countries, too, and especially in German-speaking countries, Pettenkofer’s students made careers in the civil service or became university professors and held chairs in hygiene. In addition to the foreign representatives already mentioned, Gustav Wolffhügel (1845-1899), who became a full professor in Göttingen in 1877, and Karl Bernhard Lehmann (1858-1940), who initially went to Würzburg as an associate professor in 1887 and became a full professor in 1894 with the founding of the Institute of Hygiene, should be mentioned in this context without claiming to be complete. Josef Forster (1844-1910), as full professor, also took over the direction of the new Hygiene Institute in Amsterdam in 1878, before moving to the chair of the reform-oriented university in Strasbourg in 1896. Carl Flügge (1847-1923) became the first full professor of hygiene in Breslau in 1887 and director of the Institute of Hygiene in Berlin in 1909. Friedrich Renk (1850-1928), who played an important role in the Imperial Health Office, was appointed to the new chair of hygiene by the University of Halle in 1889, Josef von Fodor (1843-1901) became a full professor in Budapest, and Aladòr von Rozshegyi (Rospahegg) in Cluj-Napoca, which also belonged to the Austro-Hungarian Habsburg Empire at the time.

 

Role model and legacy

As it turns out, Pettenkofer’s Hygiene Institute served as a model at home and abroad. Pettenkofer was used as a model for the establishment of hygienic chairs, and Pettenkofer’s institution served as a model for numerous hygiene institutes. The Munich institute also provided the impetus for the founding (1917) of the now world-famous Johns Hopkins School of Hygiene and Public Health in Baltimore. With his modern methodical awareness of hygiene, Pettenkofer inspired many physicians to follow his example and to create the basis for sound hygiene and well-founded prophylaxis through their own epidemiological and etiological studies.

After Pettenkofer was relieved of his teaching duties at the university at the end of 1893, he also resigned as director of the Institute of Hygiene in 1894. His immediate successors on the chair and as directors of the Hygiene Institute were his two students Hans Buchner (1850-1902) and, after Buchner’s early death, the Viennese professor Max von Gruber (1853-1927). Even under them, the Munich institute retained its worldwide appeal. However, research and work with bacteria now became more and more important in Munich as well.

What must not be forgotten, despite all the science, is Max von Pettenkofer’s attitude, which was deeply rooted in humanism and love of humanity. He stood in the tradition of the Enlightenment, whose principles he consistently defended: reason and science, progress and humanism. These are the core values of his impressive life’s work and his legacy.

 

 

Text (deutsch): Prof. Dr. Wolfgang Locher, Institute for Ethics, History and Theory of Medicine at LMU Munich

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Staff

Staff list only available in German. Please click here

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We congratulate Anna Weiss on receiving the VAAM PhD Award 2024 for her outstanding thesis, “Ecology of a Synthetic Gut Bacterial Community”.

We congratulate Anna Weiss on receiving the VAAM PhD Award 2024 for her outstanding thesis, “Ecology of a Synthetic Gut Bacterial Community”.

Microbiome research has long struggled with poorly understood questions, particularly regarding the role of bacterial interaction networks in the intestinal ecosystem’s functionality. Anna tackled this using the Oligo-MM model, a synthetic bacterial community developed by the Stecher group for functional microbiome research.

In her thesis, Anna explored the metabolism and strain-strain interaction network of Oligo-MM, providing a valuable resource for the broader research community (Weiss et al., The ISME Journal 2021). Her dedication to science communication is evident in her original blog, “Exploring bacterial interactions – or how to become a bacteria whisperer,” making complex scientific concepts accessible. Anna also applied novel mechanistic insights from her in vitro methodology to analyze strain-strain interactions, earning her second authorship in a Cell, Host & Microbe publication (Eberl, Weiss et al., 2021) that highlighted the microbial context’s role in colonization resistance against Salmonella infection.

In her final doctoral year, Anna addressed a pivotal question in intestinal microbiome ecology: identifying key species within a diverse community that play crucial roles in its structure and functionality. Her experimental approach, analyzing “drop-out” communities, revealed surprising results about the influence of the metabolic environment on strain-strain interactions and keystone species. This groundbreaking study, published in Nature Communications with Anna as the first author (Weiss et al., 2023), has profound implications for the field and the interpretation of microbiome signatures.

Figure 1: left to right: Prof. N. Frankenberg-Dinkel, VAAM Vice President, Dr. Anna Weiss, Prof. J. Stülke, Head of PhD Award Committee

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Novel insight into intricate epigenetics of bacteria

Maybe you have asked yourself already, since bacteria “invented” almost all biochemical matters of life (except maybe RNA), why humans have epigenetics, for example for gene silencing, and not bacteria?

Indeed this is not true, since bacteria can have even more epigenetics than humans and also use epigenetics for different purposes, for example to keep bacterial viruses (bacteriophages) out of the cell, or also for the sake of fine-tuning gene regulation. However, many details about the epigenetic mechanisms and patterns  in bacteria are unknown.

The MvPI group of Prof. Josenhans in collaboration with Prof. Suerbaum and senior research fellow Dr. Ailloud, have gained more insight into how quantitative bacterial epigenetics can be, and how variable it can become under environmental changes. Together with the doctoral researcher Lubna Patel in our graduate program, they used the stomach bacterium Helicobacter pylori which modifies its genome extensively by methyl groups, and a particular sequencing method, to find out where the genome is exactly methylated and how much. They made epigenetic maps of the whole genome and could find that certain nucleotides and certain gene networks show more epigenetic influence and fine-tuning than others. Different functions in virulence and housekeeping genes are suspected. Prof. Josenhans and coworkers therefore would like to use the new knowledge in the future to find out more about the function of the differential quantitative methylation and also use this for novel applications, for instance in antibiotic resistance research. The study was supported by DZIF. You can find more information on the publication website: doi: 10.1186/s12915-024-01921-1.

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New professor at the Max von Pettenkofer Institute – Carolin C. Wendling

On 01.04.2024, Prof. Dr. Carolin Wendling took up her position as University Professor (W2) at the Chair of Medical Microbiology and Hospital Hygiene at the Max von Pettenkofer Institute. Ms. Wendling and her research group are investigating how bacteria change genetically and how this influences their pathogenicity and antibiotic resistance.

In her research, Prof. Wendling combines concepts and methods from evolutionary biology, microbiology, molecular biology, evolutionary genomics and mathematical modeling. Her work is predominantly experimental and hypothesis-oriented. One focus of her research is the role of bacteriophages in bacterial evolution. Prof. Wendling explains: “Bacteriophages, i.e. viruses that infect bacteria, are incredibly exciting because they can exert very strong selection pressure on bacteria. This can, for example, lead to a drastic change in the virulence of a bacterium due to the presence of certain phages.”

At the Max von Pettenkofer Institute, Prof. Wendling will conduct both basic and applied research on phage therapy. The aim of the basic research is to better understand the ecological and evolutionary relationships between bacteriophages and bacteria, particularly in complex microbial communities such as the human intestinal microbiome. Her research in the field of phage therapy aims to develop alternative treatment methods for multi-resistant bacteria in the long term. Another focus of her research is the establishment of an in vivo infection model in order to reduce animal testing on mammals. To this end, the working group is developing an insect model that harbors a human-like intestinal microbiome. Prof. Wendling explains: “My aim is to develop a cost-effective alternative to reduce animal testing, but still remain as close to reality as possible.” Chair holder Prof. Sebastian Suerbaum: “My colleagues and I are very pleased that we have been able to attract Professor Wendling from Zurich to the Max von Pettenkofer Institute and LMU. Her research area fits perfectly into the existing research focus of our institute and there are excellent new opportunities for cooperation and synergies within the Max von Pettenkofer Institute, at the Munich site and beyond. We warmly welcome Carolin Wendling to the Pettenkofer Institute and wish her and her team a good start in Munich.”

About the person:
Carolin Wendling studied biology at Johannes Gutenberg University Mainz. In 2014, she completed her doctorate in evolutionary biology at Kiel University and the Alfred Wegener Institute for Polar and Marine Research under the supervision of Dr. Mathias Wegner with the thesis “Ecology and evolution of invasive Pacific oysters in response to pathogen infection and rising temperatures”. As a postdoc, she initially worked at the GEOMAR Helmholtz Center for Ocean Research in Kiel, the University of York and the ETH in Zurich. From 2019 – 2024 she led an independent junior research group at ETH Zurich.

 

 

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The genome of Helicobacter pylori provides unexpected insights into human migrations and bacterial evolution

The carcinogenic bacterium Helicobacter pylori has accompanied humans for about 100,000 years. The bacterium’s genes reflect the history of this millennia-long association and also allow conclusions to be drawn about human migration movements (Falush, …, Achtman & Suerbaum, Science 2003). The LMU microbiologist Prof. Sebastian Suerbaum, in collaboration with an international consortium of scientists, including from the Institut Pasteur in Shanghai and the University of Gothenburg in Sweden, has now been able to show with the help of new analytical methods that the Helicobacter pylori bacteria resident in Europe today are the result of several migratory movements from Africa. The exchange between the genomes of bacteria formerly resident in Europe with bacteria that African immigrants brought with them in their stomachs has made important contributions to the evolution of H. pylori and made it possible to optimise the bacterial genomes by selection. In contrast, H. pylori genomes in Asia have significantly fewer traces of African H. pylori.

The results, published in the renowned journal Nature Communications, provide a fascinating insight into the role of human migration in the evolution of this important pathogen.

Original publication: Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations. Harry Thorpe#, Elise Tourrette#, Koji Yahara#, …, Sebastian Suerbaum*, Kaisa Thorell*, Daniel Falush*.

# co-first authors; * co-last authors.

Nature Communications doi: 10.1038/s41467-022-34475-3

Link zur Originalpublikation (Open Access)

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Address
Max von Pettenkofer Institute
for Hygiene and Medical Microbiology
of the Ludwig-Maximilians-University Munich
Pettenkoferstr. 9a
80336 Munich

Internet: www.mvp.uni-muenchen.de

Chair of Medical Microbiology and Hospital Hygiene

Phone: +49 (0)89 2180 – 72855/72801
Fax: +49 (0)89 2180 – 72802
E-mail: suerbaum(at)mvp.lmu.de

Chair of Virology
Telephone: +49 (0)89 2180-72901
Fax: +49 (0)89 2180-72902
E-mail: keppler(at)mvp.lmu.de

 

Legal representatives

The Ludwig-Maximilians-Universität München is a public corporation. It is legally represented by its president.

 

The Chair of Medical Microbiology and Hospital Hygiene is represented by its holder Prof. Dr. med. Sebastian Suerbaum, Director of the Max von Pettenkofer Institute.

 

The Chair of Virology is represented by its holder Prof. Dr. med. Oliver T. Keppler, Director of the Max von Pettenkofer Institute.

 

Competent supervisory authority

Bavarian State Ministry of Science and Art, 80327 Munich, Germany

 

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DE 811205325

 

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Despite careful control of the contents, no liability is assumed for the contents to which reference is made by means of external links. The operators or authors of linked pages are solely responsible for their content.

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EDP department of the Max von Pettenkofer Institute (address as above) under the direction of Aldric Namias.

The technical support and creation of content is carried out by:

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The EDP Department of the Max von Pettenkofer Institute

Contents on the pages of the Max von Pettenkofer Institute
commissioned authors, working group

Responsible for the content according to § 10 paragraph 3 MDStV:
Management of the Max von Pettenkofer Institute or the respective chair.

Programming and technical support: Science Relations

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Vaccination Consultation


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Contact


Chair of Medical Microbiology and Hospital Epidemiology

Constanze Hartmannsgruber, M.A.

Assistant Prof. Sebastian Suerbaum
Pettenkoferstraße 9a (Raum 104)
80336 München
+49 (0)89 2180 728 05 Telefax: +49 (0)89 2180 728 02

Birgit Lang, Dipl.-Betriebswirtin

Assistant Prof. Sebastian Suerbaum
Pettenkoferstraße 9a (Raum 104)
80336 München
+49 (0)89 2180 728 01 Telefax: +49 (0)89 2180 728 02

Virology

Brigitte Held, Dipl.-Angl. BWL

Assistant to Prof. Oliver T. Keppler
Pettenkoferstraße 9a
80336 München
+49 (0)89 2180 72901 Telefax: +49 (0)89 2180 72902

Gate

Telephone Exchange

Pettenkoferstraße 9a
80336 München
Telefon: +49 (0)89 2180 728 11/12

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Medical Microbiology and Hospital Epidemiology 


At the Chair of Medical Microbiology and Hospital Hygiene, several scientific research groups work on a broad spectrum of basic science and translational projects in the field of infection biology and infectious medicine. The Chair is also home to the National Reference Center for Helicobacter pylori since 2017. The chair is also part of the Thematic Translational Unit Gastrointestinal Infections of the German Center for Infection Research. The chair holder is Prof. Dr. Sebastian Suerbaum, a specialist in microbiology, virology and infectious disease epidemiology.

 

Check out our new interactive website MIVIM

 

Current research topics of the chair

  1. Bacterial infections of the gastrointestinal tract (Helicobacter pylori, Salmonella enterica, Campylobacter jejuni/coli)
  2. The gut microbiome and its role in health and disease
  3. Innovative methods of microbiological diagnostics

In addition to the main focus areas, further research projects on current topics are carried out.

The research projects are funded by the German Research Foundation, the German Federal Ministry of Education and Research, the German Center for Infection Research, the EU, the Bavarian Research Foundation, and other foundations.

 

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Medical Microbiology and Hospital Epidemiology 


Research Group Dr. Wolfgang Fischer

The research group of Wolfgang Fischer is engaged in elucidating the molecular mechanisms of action of type IV protein secretion systems in the human pathogen Helicobacter pylori, the causative agent of diseases such as chronic gastritis, duodenal ulcers, or gastric cancer. Two major ways how these bacteria utilize such systems are the direct modulation of infected host cells by effector molecules, and the exchange of genetic material in the process of horizontal gene transfer. Specifically, the Cytotoxin-associated gene (Cag) type IV secretion system and its translocated effector protein CagA are well-established pathogenicity determinants of H. pylori, notably for the development of gastric cancer. One of our research aims is to understand the type IV secretion process of the CagA protein in mechanistic detail. A second focus of our work is to examine integrating and conjugative elements (ICEs), genome islands which may use type IV secretion systems for horizontal DNA transfer, and which have the potential for providing additional host-interaction factors to individual H. pylori strains.

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Medical Microbiology and Hospital Epidemiology 


Research Group Dr. Tobias Geiger

The Junior Research Group of Dr. Tobias Geiger studies molecular mechanisms underlying the pathogenicity of gastrointestinal and systemic pathogens such as Salmonella enterica. The interests mainly focus on protein secretion systems, secretion mechanisms, immunomodulatory effector proteins, and major virulence factors responsible for highly adapted host/pathogen interactions. Of particular interest is Salmonella enterica serovar Typhi, a facultative intracellular human pathogen and the cause of typhoid fever, a life-threatening disease, which results in more than 200,000 annual deaths worldwide. Unlike, other Salmonella enterica serovars, S. typhi exclusively infects humans where in addition to cause disease, it is capable to establish long-term persistence. In recent years, multiple antibiotic resistant strains have begun to emerge, raising the alarming prospect of untreatable typhoid fever. Thus, this situation desperately requires a greater understanding of S. typhi pathogenicity.

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Medical Microbiology and Hospital Epidemiology 


Structured doctorate program

The Max von Pettenkofer Institute (MvPI) of LMU offers a new structured international PhD program (starting winter semester 2019/2020) called “Infection Research on Human Pathogens@MvPI” under the umbrella of MMRS (https://www.graduatecenter.uni-muenchen.de/promotionsprogramme/index.html). This PhD program combines the work on an individual PhD project (natural science or medical PhD thesis) in the field of infection research (with focus on microbiology/bacterial pathogens, microbiota research, virology and infectious immunology) with program-specific side events for in-depth and comprehensive thematic rounding in central and current topics of infection research as well as further practical courses and offers on transferable skills.

Information on new projects and currently offered positions in the program can be found on the MvPI website (https://www.mvp.uni-muenchen.de/stellenangebote). Further information about the institute, the main topics worked on there and the current working groups can also be found on our institute website or can be obtained from the secretariat responsible for the PhD program at MvPI (Ms. Birgit Lang, Tel: 089-2180 72801 or Ms. Constanze Hartmannsgruber, Tel: 089-2180 72805 Email: PhD.infection(at)mvp.lmu.de).

We are currently in the process of adding a time-bound formal application procedure. Until this is done, please contact the professors and group leaders directly if you are interested in a PhD for your unsolicited application and check our “Job Opportunities” page regularly. You can also send your complete unsolicited application with two references to our office at any time (email). Thank you for your interest.

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Medical Microbiology and Hospital Epidemiology 


Founding Faculty at the Max von Pettenkofer Institute

PD Dr. Hanna-Mari Baldauf (Virology)

Prof. Dr. Christine Josenhans (Microbiology, Immunology)

Prof. Dr. Bärbel Stecher (Microbiology)

PD Dr. Wolfgang Fischer (Microbiology)

Dr. Xaver Sewald (Virology, Cell Biology)

Dr. Christian Schölz (Virology, Biochemistry)

Dr. Tobias Geiger (Microbiology, Cell Biology)

Prof. Dr. Oliver Keppler (Virology)

Prof. Dr. Sebastian Suerbaum (Microbiology)

19 Doctoral Students (First generation, natural sciences and medicine)

Secretary /Organisational coordination: Frau Lang / Frau Hartmannsgruber

Tel. +4989218072801 (administrative office)

Email: PhD.infection@mvp.lmu.de

 

 

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Research group Prof. Dr. Carolin Wendling

Our group aims to unravel how bacteria evolve in response to abiotic and biotic environmental interactions. We thereby focus on one of the most important players that influence bacterial ecology and evolution: mobile genetic elements (MGEs), including plasmids and phages, which can provide their bacterial hosts with accessory genes, such as virulence and/ or antibiotic resistance genes. By working at different levels of biological complexity, from clonal populations to complex microbial communities, we aim to elucidate phage-bacteria interactions in diverse backgrounds. Utilizing a multidisciplinary approach, we employ a diverse array of techniques such as molecular biology, experimental evolution, in vivo infection experiments, genomics, and mathematical modelling. This holistic approach enables us to explore antimicrobial resistance, infectious diseases, and phage therapy from various angles, leading to a comprehensive understanding of these complex phenomena and advancing phage therapy applications in gut infections.

Our research priorities include the following:

  1. Understanding ecological and evolutionary interactions between prophages, commensals, and pathogens in the gastro-intestinal tract
  2. Reveal the role of prophages in gut health and diseases
  3. Explore how novel insights into phage ecology and evolution can improve phage therapy

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Diagnostics


List of pathogens

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Virology


Several research groups are working on a broad range of projects ranging from basic science to translational studies related to important viral human pathogens, in part with the support of the Institute’s diagnostics team. The chair of virology is Professor Oliver T. Keppler, MD.

The current focus areas comprise:

  1. Viral persistence and immune destruction by HIV
  2. Viral evolution and immune evasion of SARS-CoV-2
  3. Antiviral strategies against HIV and SARS-CoV-2
  4. Species-specific aspects of innate immunity and HIV small animal model development
  5. Interaction of CMV with the immune system
  6. High-throughput screening technologies to identify virus-host interactions in human coronaviruses
  7. SAMHD1-dependent chemoresistance and viral replication
  8. National Reference Center for Retroviruses
  9. Bay-VOC: Molecular genetic SARS-CoV-2 surveillance network in Bavaria
  10. FOR-COVID: Bavarian research network on COVID-19

Our research projects are funded by the German Research Foundation (DFG), the German Federal Ministry of Education and Research (BMBF), the German Center for Infection Research (DZIF), the Bavarian State Ministry of Health and Care, the Bavarian State Ministry of Science and Art, the Bavarian Research Foundation, the Wilhelm Sander Foundation, and other foundations.

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